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Discovery and Roles of ER-Endolysosomal Contact Sites in Disease

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Organelle Contact Sites

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 997))

Abstract

Inter-organelle membrane contact sites (MCSs) serve as unique microenvironments for the sensing and exchange of cellular metabolites and lipids. Though poorly defined, ER-endolysosomal contact sites are quickly becoming recognized as centers for inter-organelle lipid exchange and metabolic decision-making. Here, we review the discovery and current state of knowledge of ER-endolysosomal MCSs with particular focus on the molecular players that establish and/or utilize these contact sites in metabolism. We also discuss associations of ER-endolysosomal MCS-associated proteins in human disease, as well as the therapeutic promise these contact sites hold in modulating cellular physiology.

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Acknowledgments

We would like to thank members of the Henne Lab for their helpful thoughts and suggestions during the preparation of this book chapter. WM Henne is supported by grants from the NIH NIGMS (R35GM119768-01), the Searle Foundation (SSP-2016-1482), The American Federation for Aging Research (AFAR) (A15198), the Welch Foundation (I-1873), and the UT Southwestern Endowed Scholars Program.

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  1. Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX, 75013, USA

    William Mike Henne

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  1. William Mike Henne
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Correspondence to William Mike Henne .

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Editors and Affiliations

  1. School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan

    Mitsuo Tagaya

  2. Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada

    Thomas Simmen

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Henne, W.M. (2017). Discovery and Roles of ER-Endolysosomal Contact Sites in Disease. In: Tagaya, M., Simmen, T. (eds) Organelle Contact Sites. Advances in Experimental Medicine and Biology, vol 997. Springer, Singapore. https://doi.org/10.1007/978-981-10-4567-7_10

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