Abstract
While DLIs can have a variety of clinical manifestations, drug-induced interstitial pneumonia has been found to occur at the highest frequency. The clinical feature of 165 cases of drug-induced interstitial pneumonia occurring in medical institutions across Japan was as follows. Common subjective symptoms included difficulty breathing, fever, and coughing, but there were also 17 cases that were asymptomatic. The most frequent causative drug was drug for malignant neoplasms in 92 cases. The period from the start of drug administration to the development of symptoms ranged from 2 to 8280 days, with a median of 69. The median serum KL-6 were elevated at 623 U/mL. With a normal upper limit for KL-6 of 400 U/mL, the number of cases exhibiting an elevated value was 138 cases. As treatment, the suspected drug was discontinued in 159 cases, and corticosteroids including pulse therapy were used in 132. The outcomes were relatively favorable, ranging from a complete cure to an improved condition in 142 cases, but there were 5 fatalities.
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Acknowledgments
The authors wish to thank Dr. Koichiro Tatsumi from Chiba University, Dr. Noboru Hattori from Hiroshima University, Hitoshi Tokuda from the Chuo General Hospital (now the Tokyo Yamate Medical Center), Akihiko Gemma from the Nippon Medical School, and Yoshiro Saito from the National Institute of Health Sciences (NIHS) to collect cases of drug-induced interstitial pneumonia in this study.
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Ushiki, A., Hanaoka, M. (2018). Clinical Characteristics of DLI: What Are the Clinical Features of DLI?. In: Hanaoka, M., Nakamura, H., Aoshiba, K. (eds) Drug-Induced Lung Injury. Respiratory Disease Series: Diagnostic Tools and Disease Managements. Springer, Singapore. https://doi.org/10.1007/978-981-10-4466-3_3
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DOI: https://doi.org/10.1007/978-981-10-4466-3_3
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