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Peripartum Cardiomyopathy: Do Exosomes Play a Role?

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Exosomes in Cardiovascular Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 998))

Abstract

Peripartum cardiomyopathy (PPCM) refers to irreversible cardiomyocyte damage that occurs during the last month of pregnancy, or within 5 months after giving birth. It is characterized by systolic heart failure. This life-threatening condition is relatively uncommon, but the incidence has been climbing up. Because of its high mortality, it is crucial for physicians to have high suspicious for the disease. Studies have been done to search into specific lab test and treatment for PPCM. Therapies like anti-viral, anti-inflammatory and immunosuppression regimen have been explored. New regimen like exosomes has also been explored and revealed promising effects.

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Acknowledgements

This work was supported by the grants from National Natural Science Foundation of China (81370280 and 81570332), the grant from Yangpu Commission of Science and Technology Commission, and Yangpu Commission of Health and Family Planning (YP15M07), and the “Chenguang Program” supported by Yangpu Hospital, Tongji University School of Medicine (Ye1201409).

Competing Financial Interests The authors declare no competing financial interests.

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Author notes

  1. Huanyu Gu, Qiying Dai and Zhuyuan Liu contributed equally to this work.

Authors and Affiliations

  1. Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

    Huanyu Gu, Qiying Dai, Zhuyuan Liu & Lei Zhou

  2. Metrowest Medical Center, Framingham, MA, 01702, USA

    Qiying Dai

  3. Department of Cardiology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, 200090, China

    Hongbao Wang & Jianhua Yao

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  1. Huanyu Gu
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  2. Qiying Dai
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  3. Zhuyuan Liu
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  4. Hongbao Wang
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  5. Jianhua Yao
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  6. Lei Zhou
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Correspondence to Jianhua Yao or Lei Zhou .

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Editors and Affiliations

  1. Shanghai University , Shanghai, China

    Junjie Xiao

  2. Victor Babeş National Institute of Patho , Bucharest, Romania

    Sanda Cretoiu

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Gu, H., Dai, Q., Liu, Z., Wang, H., Yao, J., Zhou, L. (2017). Peripartum Cardiomyopathy: Do Exosomes Play a Role?. In: Xiao, J., Cretoiu, S. (eds) Exosomes in Cardiovascular Diseases. Advances in Experimental Medicine and Biology, vol 998. Springer, Singapore. https://doi.org/10.1007/978-981-10-4397-0_9

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