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Exosomes in Cardiovascular Diseases pp 91–100Cite as

Exosomes as New Intercellular Mediators in Development and Therapeutics of Cardiomyocyte Hypertrophy

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 998))

Abstract

Myocardial hypertrophy is a common cardiac condition in response to hemodynamic and neurohormonal alterations. Pathological hypertrophic growth in hearts caused the decline of cardiac functions, and finally developed into congestive heart failure. The exosomes are small membrane vesicles which are secreted by various cells and play important roles in cellular communication, migration, proliferation and differentiation. Recent studies uncovered that the exosomes from cardiac fibroblasts and other tissues participates in the development of myocardial hypertrophy. Nevertheless, cardiac progenitor cells and mesenchymal stem cells-derived exosomes confer protective action on myocardial hypertrophy. Thus, the exosomes serve as new intercellular mediators between cardiomyocytes and other cells, and show broad application potential in the diagnostic and therapy of cardiomyocyte hypertrophy.

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Author information

Authors and Affiliations

  1. Department of Pharmacy, The Affiliated Second Hospital of Harbin Medical University, 157# Baojian Road, Nangang District, Harbin, 150081, Heilongjiang Province, China

    Qi Huang & Benzhi Cai

  2. Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, 150081, Heilongjiang Province, China

    Qi Huang & Benzhi Cai

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  1. Qi Huang
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  2. Benzhi Cai
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Correspondence to Benzhi Cai .

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Editors and Affiliations

  1. Shanghai University , Shanghai, China

    Junjie Xiao

  2. Victor Babeş National Institute of Patho , Bucharest, Romania

    Sanda Cretoiu

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Huang, Q., Cai, B. (2017). Exosomes as New Intercellular Mediators in Development and Therapeutics of Cardiomyocyte Hypertrophy. In: Xiao, J., Cretoiu, S. (eds) Exosomes in Cardiovascular Diseases. Advances in Experimental Medicine and Biology, vol 998. Springer, Singapore. https://doi.org/10.1007/978-981-10-4397-0_6

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