Exosomes: Outlook for Future Cell-Free Cardiovascular Disease Therapy

  • Bahar Barani
  • Sheeja Rajasingh
  • Johnson RajasinghEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 998)


Cardiovascular diseases are the number one cause of death globally with an estimated 7.4 million people dying from coronary heart disease. Studies have been conducted to identify the therapeutic utility of exosomes in many diseases, including cardiovascular diseases. It has been demonstrated that exosomes are immune modulators, can be used to treat cardiac ischemic injury, pulmonary hypertension and many other diseases, including cancers. Exosomes can be used as a biomarker for disease and cell-free drug delivery system for targeting the cells. Many studies suggest that exosomes can be used as a cell-free vaccine for many diseases. In this chapter, we explore the possibility of future therapeutic potential of exosomes in various cardiovascular diseases.


Exosomes Cardiovascular diseases Myocardial infarction Biomarker Drug delivery Nanovesicles 



Abdominal aortic aneurysm


Adipose-derived MSCs


Adipose stem cells


Bone marrow-derived MSCs


Cardiovascular diseases


Endometrium-derived MSCs


Embryonic stem cells


Extracellular vesicles


Found in inflammatory zone 1


Hypoxia-induced mitogenic factor


Heat shock protein




Induced pluripotent stem cells


Monocyte chemotactic protein 1


Myocardial infarction


Micro RNA


Messenger RNA


MSC-derived condition medium


Mesenchymal stem cells


Microvesicular body


Neonatal cardiac progenitor cell


Neonatal total condition medium


Small interfering RNAs


Vascular endothelial growth factor



This work was supported, in part, by American Heart Association Grant-in-Aid 16GRNT30950010 and National Institutes of Health COBRE grant P20GM104936 (to JR).


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Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  • Bahar Barani
    • 1
  • Sheeja Rajasingh
    • 1
  • Johnson Rajasingh
    • 1
    • 2
    Email author
  1. 1.Division of Cardiovascular Diseases, Department of Internal MedicineCardiovascular Research Institute, University of Kansas Medical CenterKansas CityUSA
  2. 2.Department of Biochemistry and Molecular BiologyUniversity of Kansas Medical CenterKansas CityUSA

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