Development of Microemulsion Containing Prednisolone

  • Minh Nguyet Pham
  • Toi Vo Van
  • Phuong Ha-Lien Tran
  • Thao Truong-Dinh Tran
Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 63)


Prednisolone, an anti-inflammatory drug with a very slight solubility (0.23 mg/mL at 25 °C), high permeability and short biological half-life (2–4 h) in oral administration was selected as the candidate drug for sustained drug release. The aim of this research is to formulate and evaluate the stable formation of oil-in-water microemulsion for enhancing the solubility of the model drug. Microemulsion containing oleic acid as oil component, Tween 20 and P188 as main surfactant and co-surfactant at different ratios were evaluated. The microemulsion was characterized by stability test, particle size, clarity, conductivity and pH value. A stable system at nano size (11.6 and 12.3 nm) which possibly enhanced drug solubility with no drug aggregation.


Prednisolone Oil-in-water microemulsion Drug release 


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This research is partially funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 106-YS.05-2015.02. We also thank to International University and Vietnam National University—Ho Chi Minh City for supporting to our research activities.


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Pharmaceutical Engineering Laboratory, Biomedical Engineering DepartmentInternational University, Vietnam National University—Ho Chi Minh CityHo Chi Minh CityVietnam
  2. 2.School of MedicineDeakin UniversityWaurn PondsAustralia

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