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Exosomes Mediate the Beneficial Effects of Exercise

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Book cover Exercise for Cardiovascular Disease Prevention and Treatment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1000))

Abstract

It is known that moderate exercise can prevent the development of cardiovascular diseases, but the exact molecular mechanisms mediating cardioprotective effect of exercise remain unknown. Emerging evidence suggests that exercise has great impact on the biogenesis of exosomes, which have been found in both interstitial fluid and circulation, and play important roles in cellular communication. Exosomes carry functional molecules such as mRNAs, microRNA, and specific proteins, which can be used in the early diagnosis and targeted therapy of a variety of diseases. Our review focus on the current knowledge on exosome production, secretion, uptake and how exercise influence exosome content. We also highlight recent research development in exosome based approach for cardiac repair.

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Authors and Affiliations

  1. Institute for Department of Cardiovascular Surgery & Cardiovascular Science, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215123, People’s Republic of China

    Yangxin Li, Chaoshan Han & Juanjuan Wang

  2. Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, People’s Republic of China

    Jin Zhou

  3. Department of Cardiology, ChangZheng Hospital, Second Military Medical University, Shanghai, 200003, People’s Republic of China

    Chun Liang

  4. College of Pharmacy & Health Sciences, Texas Southern University, Houston, TX, USA

    Kasturi Ranganna

  5. Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu, 215123, People’s Republic of China

    Yao-hua Song

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  1. Yangxin Li
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Correspondence to Yangxin Li .

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  1. Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai, China

    Junjie Xiao

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Li, Y. et al. (2017). Exosomes Mediate the Beneficial Effects of Exercise. In: Xiao, J. (eds) Exercise for Cardiovascular Disease Prevention and Treatment. Advances in Experimental Medicine and Biology, vol 1000. Springer, Singapore. https://doi.org/10.1007/978-981-10-4304-8_18

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