Abstract
Aerosol medicine exhalation through the nose (ETN) is one of promising and comprehensive treatment methods for Eosinophilic Chronic Rhinosinusitis (ECRS) with asthma. In this treatment, the patient inhales aerosol of inhaled corticosteroid (ICS) medicine from mouth using portable inhaler. Then a part of the aerosol still floats and remains in upper airway. When the patient exhales inhaled air through the nose, the aerosol is effectively transported on the walls of middle meatus and olfactory fissure. This study performed Computational Fluid Dynamics (CFD) analysis for the transport phenomena of aerosol medicine during exhalation period in order to evaluate the curative effect of ETN numerically. As a result of CFD analysis, ETN formed impinging flow toward upper wall of nasopharynx, subsequently complex swirl and circulation flow in the nasopharynx region. In addition, main flow of ETN passed upper region of nasal cavity. Such the tendencies affected on aerosol transport characteristics; a part of aerosol particles moved into ethmoindal sinuses.
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References
Kohno, T., Yamamoto, Y., Kurokawa, M.: Effect of inhaled corticosteroid on allergic rhinitis, Asthma, 19(4), 72–76 (2006)
Kobayashi, Y., Asako, M., Kanda, A., Tomoda, K., Yasuba, H.: A novel therapeutic use of HFA-BDP metered-dose inhaler for asthmatic patients with rhinosinusitis: Case series. Int. J. Clin. Pharm. Th., 52, 914–919 (2014)
Materialize Inc.: Mimics Users Guide. Materialize Inc, Leuven, Belgium (2014)
Yeh, H.C., Schum, G.M.: Models of human lung airways and their application to inhaled particle deposition. Bulletin of Mathematical Biology, 42, 461–480 (1980)
Schum, G.M., Yeh, H.C.: Theoretical evaluation of aerosol deposition in anatomical models of mammalian lung airways. Bulletin of Mathematical Biology, 42, 1–5 (1980)
Lorensen, W.E., Cline, H.E.: Marching Cubes – A high resolution 3D surface construction algorithm. In: 14th annual Conf. Computer-graphics and Interactive Techniques, New York, USA (1987)
ANSYS Japan Inc.: ANSYS ICEM CFD Release 15.0 Manual. ANSYS Japan Inc., Tokyo, Japan (2014)
ANSYS Japan Inc.: ANSYS CFX-Solver Theory Guide Release 15.0, ANSYS Japan Inc., Tokyo, Japan (2014)
Jeong, S.J., Kim, W.S.: Numerical investigation on the flow characteristics and aerodynamic force of the upper airway of patient with obstructive sleep apnea using computational fluid dynamics. Medical Engineering & Physics, 29(6), 639–651 (2009).
Gemci, T., Ponyavin, V., Chen, Y., et al.: Computational model of airway in upper generations of human respiratory tract. Biomechanics, 27, 2047–2054 (2008)
Mylavarapu, V., Murugappan, S., Mihaescu, M., et al.: Validation of computational fluid dynamics methodology used for human upper airway flow simulations. Biomechanics, 42(10), 1553–1559 (2009)
Yamamoto, T., Nakata, S., Monya, M.: Computational Fluid Dynamics for intranasal heat and mass transfer. Oto-rhino-laryngology Tokyo, 52(1), 24–29 (2009)
Kuroda, K., Yamamoto, T., Hirose, T.: CFD analysis for medicinal aerosol transport characteristics in nasal cavity flow. In: JSME Bioengineering Conference 2015, 181. JSME, Tokyo (2015)
Doorly D.J., Taylor D.J., Schroter R.C.: Mechanics of airflow in the human nasal airways. Respiratory Physiology & Neurobiology, 163(1-3), 100–110 (2008)
Nomura T., Ushio M., Kondo K., Yamasoba T.: Effects of nasal septum perforation repair surgery on three-dimensional airflow: an evaluation using computational fluid dynamics. Eur. Arch. Oto-Rhino-Laryngology, 272(11), 3327–3333 (2015)
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Yamamoto, T., Kobayashi, Y., Shikano, S., Takeyama, M., Asako, M., Tomoda, K. (2017). Flow Visualization for Nasal Cavity Flow in Aerosol Exhalation Through Nose Treatment. In: Goh, J., Lim, C., Leo, H. (eds) The 16th International Conference on Biomedical Engineering. IFMBE Proceedings, vol 61. Springer, Singapore. https://doi.org/10.1007/978-981-10-4220-1_11
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DOI: https://doi.org/10.1007/978-981-10-4220-1_11
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