Skip to main content
SpringerLink
Log in

EFFECT OF CHEMICALLY-SYNTHESIZED SILVER NANOPARTICLES (AG-NP) ON GLYCEMIC AND LIPIDEMIC STATUS IN RAT MODEL

  • Conference paper
  • First Online:
CMBEBIH 2017

Part of the book series: IFMBE Proceedings ((IFMBE,volume 62))

Abstract

The aim of present study was to investigate the effects of chemically synthesized of silver nanoparticles (Ag-NP) using citrate on selected blood biochemical parameters includes glucose, total cholesterol, triglyceride and total protein in rats model. In this study Ag-NP was synthesized with the usage of chemical reduction method. Laboratory rats were divided into four groups; control, placebo, and groups received 100 and 200 mg/kg BW of Ag-NP. Blood samples were taken, 15 days after administration, and separated serum was used for determination of biochemical measures. Greater dosage of Ag-NP (200 mg/ kg BW) causes mortality in experimental group, due to possible toxic effect of chemically synthesizedAg-NP. In serum biochemical measures infusion of Ag-NP had decreases serum glucose level (92 and 91 ml/dl in compared with control: 109 ml/dl), and total cholesterol and triglyceride had increases following Ag-NP administration (P< 0.01). In conduction, peripherally administration of chemically-synthesized Ag-NP in 100-200 mg/Kg of BW dosages, cause hypo-glycemic and hyper-lipidemic effects, due to increases peripheral glucose and decreases total cholesterol and triglyceride levels in rat model. The administration of greater dosage may cause mortality of experimental animals.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Oberdörster G, Oberdörster E, Oberdörster, “An emerging discipline evolving from studies of ultrafine particles”. Environ Health Perspect, 2005, 113:823–839.

    Google Scholar 

  2. Marin S, Vlasceanu GM, Tiplea RE, Bucur IR, Lemnaru M, Marin MM, Grumezescu AM, “ Applications and toxicity of silver nanoparticles: a recent review”. Curr Top Med Chem, 2015, 15(16):1596-1604.

    Google Scholar 

  3. Zhang T, Wang L, Chen Q, Chen C, “Cytotoxic potential of silver nanoparticles”. Yonsei Med J. 2014, 55(2):283-291.

    Google Scholar 

  4. Hussain S, Hess K, Gearhart J, Geiss K, Schlager J. “In vitro toxicity of nanoparticles in BRL3A rat liver cells”. ToxicolVitr. 2005, 19: 975–983.

    Google Scholar 

  5. Brown JS, Zeman KL, Bennett WD. “Ultrafine particle deposition and clearance in the healthy and obstructed lung”. Am J RespirCrit Care Med. 2002, 166: 1240–1247.

    Google Scholar 

  6. Reidy B, Haase A, Luch A, Dawson KA, Lynch I. “Mechanisms of silver nanoparticle release, transformation and toxicity: a critical review of current knowledge and recommendations for future studies and applications”. Materials, 2013, 6: 2295-2350.

    Google Scholar 

  7. Ebabe Elle R, Gaillet S, Vidé J, Romain C, Lauret C, Rugani N, Cristol JP, Rouanet JM” Dietary exposure to silver nanoparticles in Sprague-Dawley rats: effects on oxidative stress and inflammation”. Food ChemToxicol, 2013, 60: 297-301.

    Google Scholar 

  8. Adeyemi O.S., T. O. Faniyan. 2014. Antioxidant status of rats administered silver nanoparticles orally. Journal of Taibah University Medical Sciences, 9: 182-186.

    Google Scholar 

  9. Sulaiman F.A., M.A. Akanji, H.O.B. Oloyede, A.A. Sulaiman, A. Olatunde, E.B. Joel, T.H. Adewale, H.A. Adeboye, S.O. Idris, A.L. Quadri, R.A. Oyegoke and O.S. Adeyemi, 2015a. Oral Exposure to Silver/Gold Nanoparticles: Status of Rat Lipid Profile, Serum Metabolites and Tissue Morphology. Journal of Medical Sciences, 15: 71-79.

    Google Scholar 

  10. Hritcu, L., M. Stefan, L.Ursu, A. Neagu, M. Mihasan, L.Tartau, V. Melnig. Exposure to silver nanoparticles induces oxidative stress and memory deficits in laboratory rats. Cent. Eur. J. Biol., 2011, 6(4): 497-509.

    Google Scholar 

  11. Heidary, T, FK Shayesteh, H Ghasemi, SMH Zijoud, ARanjbar. Effects of silver nanoparticle (Ag NP) on oxidative stress, liver function in rat: hepatotoxic or hepatoprotective?. Issues in Biological Sciences and Pharmaceutical Research, 2014, 2: 40-44.

    Google Scholar 

  12. Lee, MJ, Lee, SJ, Yun, SJ, Jang, JY, Kang, HG, Kim, K, Choi, IH, Park, S. Silver nanoparticles affect glucose metabolism in hepatoma cells through production of reactive oxygen species. Int. J. Nanomed. 2016, 11: 55–68.

    Google Scholar 

  13. Razavian MH, Masaimanesh M Ingestion of silver nanoparticles leads to changes in blood parameters, Nanomed. J., 2015, 1(5): 339-345.

    Google Scholar 

  14. Bahrami A M, Hosseini E, Shaddel M. Effects of Silver Nanoparticles on the Serum Parameters in Mice. Ann. Mil. Health Sci. Res., 2015, 13 (4):140-145.

    Google Scholar 

  15. Sulaiman F.A., O.S. Adeyemi, M.A. Akanji, H. O. BukoyeOloyede, A. A. Sulaiman, A. Olatunde, A.A. Hoseni, Y.V. Olowolafe, R. N. Nlebedim, H. Muritala, M. OlugbemiroNafiu, M.O. Salawu. Biochemical and morphological alterations caused by silver nanoparticles in Wistar rats. Journal of Acute Medicine, 2015, 5: 96–102.

    Google Scholar 

  16. Jarrar, Q., A. Battah, F. Obeidat and K. Battah. “ Biochemical changes induced by the toxicity of variable sizes of silver nanoparticles”. British J Pharmaceut Res, 2014, 4: 2670-2678.

    Google Scholar 

  17. Park, K, Park EJ, Chun IK, Choi K, Lee SH, Yoon J, Lee BC. Bioavailability and toxicokinetics of citrate-coated silver nanoparticles in rats. Arch. Pharm. Res. 2011, 34(1): 153-158.

    Google Scholar 

  18. Kamali M, Ghorashi, AA, Asadollahi M A. “Controllable synthesis of silver nanoparticles using citrate as complexing agent: characterization of nanoparticles and effect of pH on size and crystallinity. Iran. J. Chem. Chem. Eng. 2012, 31: 21-28.

    Google Scholar 

  19. Mostafa, A.A., R.M. Shaban, Essam S.N. Solkamy. “Evaluation of Biological Activities of Chemically Synthesized Silver Nanoparticles”. J. Nanomaterials. 2015, Article ID: 789178. doi:10.1155/2015/78917

  20. Rainville LC, Carolan D, Varela AC, Doyle H, Sheehan D. “Proteomic evaluation of citrate-coated silver nanoparticles toxicity in Daphnia magna”. Analyst . 2014, 139(7):1678-1686.

    Google Scholar 

  21. Ranjbar Z, Ataie F, Khajavi H. “Effects of silver nanoparticle (Ag NP) on oxidative stress biomarkers in rat”. Nanomed J. 2014, 1: 205-210.

    Google Scholar 

  22. Virgen-ortiz A, limón-miranda S, Soto-covarrubias MA, Apolinar-iribe A, Rodríguez-león E, R. iñiguez-palomares. “Biocompatible silver nanoparticles synthesized using rumexhymenosepalus extract decreases fasting glucose levels in diabetic rats”. Digest Journal of Nanomaterials and Biostructures. 2015, 10: 927 - 933

    Google Scholar 

  23. Shaluei F, Hedayati A, Jahanbakhshi A, Kolangi H, Fotovat M. “Effect of subacute exposure to silver nanoparticle on some hematological and plasma biochemical indices in silver carp (Hypophthalmichthysmolitrix)”. Hum ExpToxicol. 2013, 32(12):1270-127.

    Google Scholar 

  24. Monfared A, Bahrami AM, Hosseini E, Soltani S, Shaddel M. “Effects of Nano-particles on Histo-pathological changes of the fish”. Journal of Environmental Health Science and Engineering, 2015, 13: 62. http://doi.org/10.1186/s40201-015-0216-9

  25. Kim YS, Song MY, Park JD, Song KS, Ryu HR, Chung YH, Chang HK, Lee JH, Oh KH, Kelman BJ, Hwang IK, Yu IJ. “Subchronic oral toxicity of silver nanoparticles”. Part FibreToxicol. . 2010, 7: 20. doi: 10.1186/1743-8977-7-20.

  26. Grinceviciute N, Verdes D, Snitka V. “Effect of Zinc Oxide and Titanium Dioxide Nanoparticles on Supported Lipid Bilayers”. J Nanomed Res. 2015, 2(3): 00030.

    Google Scholar 

  27. Manke A, Wang L, Rojanasakul Y. “Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity”. BioMed Res Int. 2013, Article ID 942916. doi:10.1155/2013/942916.

  28. Patlolla AK, Hackett D, Tchounwou PB. “Silver nanoparticle-induced oxidative stress-dependent toxicity in Sprague-Dawley rats”. Mol Cell Biochem, 2015, 399(1-2): 257-268.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Young Researchers and Elite Club, Ilkhchi Branch, Islamic Azad University, Ilkhchi, Iran

    Alireza Lotfi & Elham Ghavidel Aghdam

  2. Ilkhchi Branch, Islamic Azad University, Ilkhchi, Iran

    Mohammad Narimani-Rad

Authors
  1. Alireza Lotfi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Elham Ghavidel Aghdam
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mohammad Narimani-Rad
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alireza Lotfi .

Editor information

Editors and Affiliations

  1. Faculty of Engineering and Information Technologies, International Burch University , Sarajevo, Bosnia and Herzegovina

    Almir Badnjevic

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Nature Singapore Pte Ltd.

About this paper

Cite this paper

Lotfi, A., Aghdam, E.G., Narimani-Rad, M. (2017). EFFECT OF CHEMICALLY-SYNTHESIZED SILVER NANOPARTICLES (AG-NP) ON GLYCEMIC AND LIPIDEMIC STATUS IN RAT MODEL. In: Badnjevic, A. (eds) CMBEBIH 2017. IFMBE Proceedings, vol 62. Springer, Singapore. https://doi.org/10.1007/978-981-10-4166-2_25

Download citation

  • DOI: https://doi.org/10.1007/978-981-10-4166-2_25

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-4165-5

  • Online ISBN: 978-981-10-4166-2

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation