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Physeal Regeneration: From Bench to Bedside

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Regenerative Medicine: Laboratory to Clinic

Abstract

Physeal injury leading to growth arrest in children is a problem requiring regenerative solutions to restore normal growth activity. This article touches on the structure and function of the growth plate, the injuries and the resultant growth plate arrests, methods of imaging and assessing growth arrest, and conventional treatment. The cell-based strategies for growth plate repair have been discussed in details including the methods of culture, control of differentiation and expansion, scaffolds, and bioreactors. Characterization and release criteria for chondrocytes for transplantation are also suggested. Finally, preclinical and clinical studies have been discussed.

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Abbreviations

ECM:

Extracellular matrix

GAG:

Glycosaminoglycan

GMP:

Good manufacturing practice

Ihh:

Indian hedgehog

PLGA:

Poly lactic-co-glycolic acid

PTHrP:

Parathyroid hormone-related protein

TUNEL:

Terminal deoxynucleotidyl transferase dUTP nick end labeling

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Acknowledgments

Department of Biotechnology, Government of India, and Fluid research grant provided by Christian Medical College, Vellore for funding the preclinical and clinical studies.

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Authors and Affiliations

  1. Paediatric Orthopaedic Unit and Center for Stem Cell Research, Christian Medical College, Vellore, Tamil Nadu, India

    Vrisha Madhuri M.S., M.Ch. (L’pool), Karthikeyan Rajagopal & Sowmya Ramesh

Authors
  1. Vrisha Madhuri M.S., M.Ch. (L’pool)
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  2. Karthikeyan Rajagopal
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  3. Sowmya Ramesh
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Corresponding author

Correspondence to Vrisha Madhuri M.S., M.Ch. (L’pool) .

Editor information

Editors and Affiliations

  1. Stem Cell Biology Laboratory, National Institute of Immunology, New Delhi, India

    Asok Mukhopadhyay

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Madhuri, V., Rajagopal, K., Ramesh, S. (2017). Physeal Regeneration: From Bench to Bedside. In: Mukhopadhyay, A. (eds) Regenerative Medicine: Laboratory to Clinic. Springer, Singapore. https://doi.org/10.1007/978-981-10-3701-6_27

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