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Blood to Blood: A New Therapeutic Opportunity for Age-Related Diseases

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Regenerative Medicine: Laboratory to Clinic

Abstract

Aging is a progressive accumulation of changes with time that are associated with loss of physiological integrity and impaired functions, responsible for ever-increasing susceptibility to diseases and vulnerability to death. It is one of the strongest risk factors for diseases due to decline in regenerative capacity. This regenerative failure has been linked to decline in systemic factors and elevation of pro-inflammatory cytokines that impede stem cell function and stem cell niche. Recently, heterochronic parabiosis involving surgical attachment of young and old animals sharing common vasculature has revealed that systemic environment has a profound effect on stem cell function and may restore regeneration process and even reverse human tissue aging. Circulatory growth factors from young animals have been shown to reverse age-related cardiac hypertrophy, increase neurogenesis and synapses, rejuvenate and re-modulate skin tissue and rejuvenate stem cell niche revealing a new therapeutic opportunity for aging and age-related diseases in humans.

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Abbreviations

ASES:

American Shoulder and Elbow Surgeons score

CTRI:

Clinical Trials Registry of India

DFU:

Diabetes foot ulcer

GFC:

Growth factor concentrate

MSC:

Mesenchymal stem cells

PRTEE:

Patient-rated tennis elbow evaluation

RAWM:

Radial arm water maze

VAS:

Visual analogue score

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Acknowledgements

The author is thankful to the management of Kasiak Research and Aureostem Research for providing generous support. Their generosity was instrumental for the study accomplishment, and I appreciate it. The author is thankful to Dr. Gema Sevilla, Instituto Medico Laser, Madrid Spain; Dr. Rachita Dhurat, Lokmanya Tilak Municipal Medical College and Hospital, Sion, Mumbai, India; and Dr. Geetanjali Shetty, Goregaon, Mumbai, India, for participating in the clinical studies. The author also thanks IITB-Monash Research Academy; Indian Institute of Technology (IIT), Mumbai; and Invitrogen BioServices, Bangalore, India, for the analysis of blood-derived signalling factors. The author thanks all the supporting staff and technicians for the technical and scientific support.

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  1. Aureostem Research Private Limited, 2035, Sobha Jasmine, Outer Sarjapur Ring Road, Bellandur, Bengaluru, 560103, Karnataka, India

    Satish Totey Ph.D.

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Correspondence to Satish Totey Ph.D. .

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  1. Stem Cell Biology Laboratory, National Institute of Immunology, New Delhi, India

    Asok Mukhopadhyay

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Totey, S. (2017). Blood to Blood: A New Therapeutic Opportunity for Age-Related Diseases. In: Mukhopadhyay, A. (eds) Regenerative Medicine: Laboratory to Clinic. Springer, Singapore. https://doi.org/10.1007/978-981-10-3701-6_26

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