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Recurrent Primary Sclerosing Cholangitis in Comparison with Native Primary Sclerosing Cholangitis

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Pathology of the Bile Duct

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Abstract

This chapter covers primary sclerosing cholangitis (PSC) and its overlap with autoimmune hepatitis (AIH) and liver transplantation (LT) for PSC. Histologic findings similar to those of PSC are known to occur in liver allografts transplanted for PSC; this is thought to be a recurrence of the original PSC. We mainly focus on characterizing the histologic features of recurrent PSC after LT with an emphasis on the overlap of active hepatitis and hilar xanthogranulomatous cholangitis with respect to outcome. These histologic findings may represent an important and unrecognized cause of progressive deterioration followed by cirrhotic transformation in recurrent PSC after LT.

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Authors and Affiliations

  1. Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan

    Aya Miyagawa-Hayashino & Hironori Haga

  2. Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan

    Aya Miyagawa-Hayashino

Authors
  1. Aya Miyagawa-Hayashino
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  2. Hironori Haga
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Correspondence to Aya Miyagawa-Hayashino .

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Editors and Affiliations

  1. Department of Pathology, Shizuoka Cancer Center, Shizuoka, Japan

    Yasuni Nakanuma

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Miyagawa-Hayashino, A., Haga, H. (2017). Recurrent Primary Sclerosing Cholangitis in Comparison with Native Primary Sclerosing Cholangitis. In: Nakanuma, Y. (eds) Pathology of the Bile Duct. Springer, Singapore. https://doi.org/10.1007/978-981-10-3500-5_7

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  • DOI: https://doi.org/10.1007/978-981-10-3500-5_7

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-3499-2

  • Online ISBN: 978-981-10-3500-5

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