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Cellular Senescence and Biliary Disorders

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Pathology of the Bile Duct

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Abstract

Cellular senescence is defined as a permanent growth arrest caused by several cellular injuries such as oncogenic mutations and oxidative stress. Interestingly, senescent cells are not only results of cellular damage but also may play important roles in modulating inflammation and carcinogenesis via production of senescence-associated secretory phenotypes (SASPs) including various cytokines and chemokines. Cellular senescence may be involved in the pathophysiology of various liver diseases including cholangiopathy, a category of chronic liver diseases in which cholangiocytes are affected. Primary biliary cholangitis (PBC) is a representative cholangiopathy in which cellular senescence participates in the acceleration of inflammation and progressive ductopenia. Cellular senescence may be due to dysregulated autophagy, which may cause autoimmune process via abnormal expression of mitochondrial antigen in PBC. An involvement of cellular senescence is also reported in other cholangiopathies such as primary sclerosing cholangitis and biliary atresia. Furthermore, “oncogene-induced senescence” (OIS) may participate in multistep carcinogenesis of cholangiocarcinoma. Cellular senescence could be promising targets for prevention, early diagnosis, and therapy of various cholangiopathies in near future.

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  1. Department of Human Pathology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan

    Motoko Sasaki MD, PhD

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  1. Department of Pathology, Shizuoka Cancer Center, Shizuoka, Japan

    Yasuni Nakanuma

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Sasaki, M. (2017). Cellular Senescence and Biliary Disorders. In: Nakanuma, Y. (eds) Pathology of the Bile Duct. Springer, Singapore. https://doi.org/10.1007/978-981-10-3500-5_4

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