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Pathology of Intrahepatic Cholangiocarcinoma: Peripheral and Perihilar Type

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Pathology of the Bile Duct

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Abstract

Intrahepatic cholangiocarcinomas exhibit histological diversity in terms of morphological architectures, background liver diseases, mucin production, stromal reactions of inflammatory cells or fibrosis, the presence of premalignant lesions, and the coexistence of metastatic lesions. ICCs are classified according to anatomical location and histological characteristics as perihilar large duct type and peripheral small duct type. The different biological and molecular features of the two types of ICC support the hypothesis that perihilar type ICC and peripheral type ICC arise from different backgrounds, different carcinogenic pathways, and different cell origins. It may be important to understand these differences of tumor characteristics for the clinical management of ICCs.

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Authors and Affiliations

  1. Department of Pathology and Microbiology, Faculty of Medicine, Saga University, Nabeshima, 849-8501, Saga, Japan

    Shinichi Aishima

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  1. Shinichi Aishima
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Correspondence to Shinichi Aishima .

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  1. Department of Pathology, Shizuoka Cancer Center, Shizuoka, Japan

    Yasuni Nakanuma

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Aishima, S. (2017). Pathology of Intrahepatic Cholangiocarcinoma: Peripheral and Perihilar Type. In: Nakanuma, Y. (eds) Pathology of the Bile Duct. Springer, Singapore. https://doi.org/10.1007/978-981-10-3500-5_12

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  • DOI: https://doi.org/10.1007/978-981-10-3500-5_12

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  • Online ISBN: 978-981-10-3500-5

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