Abstract
The 3′-modified oligonucleotides using aromatic moieties, such as benzene(B)-pyridine(P) analogs (BP-type) and so on, showed prominent nuclease resistance, especially in vivo, and strong RNAi activity. One of non-coding RNAs ranging from 20 to 23 nucleotides in length is naturally occurring microRNAs (miRNAs) that are post-transcriptional regulators of gene expression. The chemically modified miRNAs for genome therapy is easy, inexpensive, and practical. The miRNA replacement therapy using these 3′-modified miRNAs may prove useful for the development of anti-cancer RNA medicine.
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Kitade, Y., Mori, T., Akao, Y. (2017). Chemical Modification of the 3′-Dangling End of Small Interfering RNAs Such as siRNAs and miRNAs: The Development of miRNA Replacement Therapy. In: Tomioka, K., Shioiri, T., Sajiki, H. (eds) New Horizons of Process Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-10-3421-3_18
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DOI: https://doi.org/10.1007/978-981-10-3421-3_18
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