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Biomaterials Based Strategies for Engineering Tumor Microenvironment

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Book cover Advances in Biomaterials for Biomedical Applications

Part of the book series: Advanced Structured Materials ((STRUCTMAT,volume 66))

Abstract

Tissue engineering aims to gain mechanistic insights into human diseases and to develop new treatment protocols. Although 2-dimensional (2-D) flat petri dish culture and in vivo disease-based models are the industrial gold standards for understanding the underlying disease pathophysiology and for drug screening/testing, they are associated with certain limitations. While the 2-D cell culture systems fail to mimic in vivo signaling, animal-based disease models are associated with long incubation period, high cost, ethical constraints as well as depiction of human pathology in different species. Therefore, there has been a paradigm shift towards the development of 3-dimensional (3-D) based in vitro disease models. These models act as bridging gaps between the aforementioned conventional strategies thereby fastening clinical translation. In this regard, biomedical engineering plays a key role towards the development of tissue engineering based 3-D disease models. These models have demonstrated success in recapitulating human diseases in terms of in vivo morphology and signaling. This chapter will present examples of biomaterials-based 3-D engineered disease models with a focus on cancer.

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Abbreviations

2-D:

Two-dimensional

3-D:

Three-dimensional

α-SMA:

α-smooth muscle actin

ABC:

ATP-binding cassette

bFGF:

Basic fibroblast growth factor

CAFs:

Cancer-associated fibroblasts

CAM-DR:

Cell-adhesion mediated drug resistance

CCL2:

Chemokine CC-motive ligand 2

CNS:

Central nervous system

CSCs:

Cancer stem cells

CSFs:

Colony stimulating factors

CSF1:

Colony stimulating factor 1

DCIS:

Ductal carcinoma in situ

DEAE:

Diethylaminoethyl

E-cad:

Epithelial-cadherin

ECM:

Extracellular matrix

EGF:

Epidermal growth factor

EGFR:

Epidermal growth factor receptor

EMT:

Epithelial to mesenchymal transition

EPC:

Endothelial progenitor cell

FAP:

Fibroblast activation protein

Fe3O4 :

Iron oxide

GA:

Glutaraldehyde

GAG:

Glycosaminoglycan

G-CSF:

Granulocyte colony stimulating factor

GEMs:

Global eukaryotic microcarriers

GM-CSF:

Granulocyte macrophage colony stimulating factor

HA:

Hyaluronic acid

HCC:

Hepatocellular carcinoma cells

HGF:

Hepatocyte growth factor

HIF-1:

Hypoxia-inducible transcription factor 1

HMF:

Human mammary fibroblasts

HPV 16:

Human papilloma virus 16

HTS:

High throughput screening

IGF1:

Insulin-like growth factor 1

IL-6:

Interleukin-6

IL-8:

Interleukin-8

MFs:

Myofibroblasts

MMPs:

Matrix metalloproteases

MP:

Microparticles

N-cad:

Neural-cadherin

NO:

Nitric oxide

NSCLS:

Non-small cell lung cancer

PCL:

Poly(ε-caprolactone)

PDGF:

Platelet-derived growth factor

PDT:

Photodyanmic therapy

PEG:

Polyethylene glycol

PHEMA:

Polyhydroxyethylmethacrylate

PLA:

Polylactide

PLG:

Poly(lactide-co-glycolide)

PLGA:

Polylactic-co-glycolide

PLLA-b-PEG-folate:

Polyl-lactic acid-b-polyethylene glycol-folate

PVA:

Polyvinyl alcohol

RCCS:

Rotary cell culture system/bioreactor

RGD:

Arginine-glycine-aspartic acid

RTK:

Receptor tyrosine kinase

SCLC:

Small cell lung cancer

SDF1:

Stromal-cell derived factor 1

sECM:

Synthetic ECM

SV-40:

Simian virus 40

TAMs:

Tumor associated macrophages

TCPS:

Tissue culture polystyrene

TE:

Tissue engineering

TGFβ:

Transforming growth factor β

TNF-α:

Tumor necrosis factor α

VEGF:

Vascular endothelial growth factor

VPF:

Vascular permeability factor

ZnPcSmix :

Zinc sulfophthalocyanine

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Acknowledgement

NA would like to acknowledge the Department of Science and Technology, India for providing DST Inspire Faculty fellowship as well as All India Institute of Medical Sciences Bhopal, India as host institution. AF would like to acknowledge the University of South Australia as host institution.

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Authors and Affiliations

  1. Department of Biochemistry, All India Institute of Medical Sciences Bhopal, Saket Nagar, Bhopal, 462020, Madhya Pradesh, India

    Neha Arya

  2. University of South Australia, Future Industries Institute, University Blv, Mawson Lakes, SA, 5095, Australia

    Aurelien Forget

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  1. Neha Arya
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Correspondence to Neha Arya .

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  1. Nuclear Agriculture & Biotechnology Div, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India

    Anuj Tripathi

  2. Nuclear Agriculture & Biotechnology Div, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India

    Jose Savio Melo

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Arya, N., Forget, A. (2017). Biomaterials Based Strategies for Engineering Tumor Microenvironment. In: Tripathi, A., Melo, J. (eds) Advances in Biomaterials for Biomedical Applications. Advanced Structured Materials, vol 66. Springer, Singapore. https://doi.org/10.1007/978-981-10-3328-5_8

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