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Biomaterials for Induction and Treatment of Autoimmunity

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Advances in Biomaterials for Biomedical Applications

Part of the book series: Advanced Structured Materials ((STRUCTMAT,volume 66))

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Abstract

Use of biomaterials in autoimmunity research is widely explored, as an adjuvant to induce antigen specific immune responses, for facilitating induction of experimental models to study disease pathogenesis and for designing novel therapeutic targets. Similarly, polymeric biomaterials are explored as a delivery vehicle for sustained and specific release of auto-antigens/drugs to treat autoimmune disorders. Although considered as biocompatible, implantation/injection of polymers like silica and metallic implants are associated with development of chronic inflammation and autoimmunity. Despite these compatibility concerns, biomaterials are still considered as favorable materials for several applications in the autoimmunity field.

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Abbreviations

APCs:

Antigen presenting cells

ASIA:

Adjuvant induced autoimmune syndrome

bFGF:

Basic fibroblast growth factor

CFA:

Complete Freund’s adjuvant

CIA:

Collagen induced arthritis

CII:

Collagen type II

CS:

Chitosan

DCs:

Dendritic cells

EAE:

Experimental autoimmune encephalomyelitis

EAU:

Experimental autoimmune uveoretinitis

HA:

Hyaluronic acid

LSECs:

Liver sinusoidal endothelial cells

MS:

Multiple sclerosis

NGF:

Nerve growth factor

NPs:

Nanoparticles

PHCCC:

N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide

PLGA:

Poly(lactic-co-glycolic acid)

PNiPAAm:

Poly-N-isopropylacrylamide

Treqs:

T regulatory cells

TCR:

T cell receptor

VUR:

Vesicoureteral reflux

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Authors and Affiliations

  1. Chemical Engineering Department, Texas Tech University, Lubbock, TX, 79409-3121, USA

    Akhilesh Kumar Shakya

  2. Medical Immunopharmacology Research, Southern Medical University, Guangzhou, China

    Kutty Selva Nandakumar

  3. Medical Inflammation Research, Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

    Kutty Selva Nandakumar

Authors
  1. Akhilesh Kumar Shakya
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  2. Kutty Selva Nandakumar
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Corresponding author

Correspondence to Akhilesh Kumar Shakya .

Editor information

Editors and Affiliations

  1. Nuclear Agriculture & Biotechnology Div, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India

    Anuj Tripathi

  2. Nuclear Agriculture & Biotechnology Div, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India

    Jose Savio Melo

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Shakya, A.K., Nandakumar, K.S. (2017). Biomaterials for Induction and Treatment of Autoimmunity. In: Tripathi, A., Melo, J. (eds) Advances in Biomaterials for Biomedical Applications. Advanced Structured Materials, vol 66. Springer, Singapore. https://doi.org/10.1007/978-981-10-3328-5_4

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