Skip to main content
SpringerLink
Log in

Physiology of Ageing

  • Chapter
  • First Online:
Geriatric Medicine

  • 2028 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Taffett GE. Physiology of aging. In: Cassel CK, Leipzig R, Cohen HJ, Larson EB, Meier DE, editors. Geriatric medicine: an evidence-based approach. 4th ed. New York: Springer; 2003. http://link.springer.com/content/pdf/10.1007/b97639.pdf#page=50 .

    Google Scholar 

  2. Mair W, Goymer P, Pletcher SD, Partridge L. Demography of dietary restriction and death in Drosophila. Science. 2003;301(5640):1731–3. sciencemag.org

    Article  CAS  PubMed  Google Scholar 

  3. Cencioni C, Spallotta F, Mai A, Martelli F, Farsetti A, Zeiher AM, Gaetano C. Sirtuin function in aging heart and vessels. J Mol Cell Cardiol. 2015;83(June):55–61. researchgate.net

    Article  CAS  PubMed  Google Scholar 

  4. Adler AS, SaurabhSinha TLAK, Zhang JY, Segal E, Chang HY. Motif module map reveals enforcement of aging by continual NF-κB activity. Genes Dev. 2007;21(24):3244–57. genesdevcshlporg

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Cencioni C, Spallotta F, Martelli F, Valente S, Mai A, Zeiher AM, Gaetano C. Oxidative stress and epigenetic regulation in ageing and age-related diseases. Int J Mol Sci. 2013;14(9):17643–63.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Collado M, Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell. 2007;130(2):223–33. Elsevier

    Article  CAS  PubMed  Google Scholar 

  7. Shay JW, Wright WE. Hayflick, his limit, and cellular ageing. Nat Rev Mol Cell Biol. 2000;1(1):72–6. nature.com

    Article  CAS  PubMed  Google Scholar 

  8. Strait JB, Lakatta EG. Aging-associated cardiovascular changes and their relationship to heart failure. Heart Fail Clin. 2012;8(1):143–64.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Olivetti G, Melissari M, Capasso JM, Anversa P. Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ Res. 1991;68(6):1560–8.

    Article  CAS  PubMed  Google Scholar 

  10. Lieb W, Xanthakis V, Sullivan LM, JayashriAragam MJP, Larson MG, Benjamin EJ, Vasan RS. Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the Framingham Offspring Study. Circulation. 2009;119(24):3085–92.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Janssens JP, Pache JC, Nicod LP. Physiological changes in respiratory function associated with ageing. Eur Resp J. 1999;13(1):197–205. Wiley Online Library

    Article  CAS  Google Scholar 

  12. Lindeman RD, Tobin J, Shock NW. Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc. 1985;33(4):278–85. Wiley Online Library

    Article  CAS  PubMed  Google Scholar 

  13. Fuiano G, Sund S, Mazza G, Rosa M, Caglioti A, Gallo G, Natale G, et al. Renal hemodynamic response to maximal vasodilating stimulus in healthy older subjects. Kidney Int. 2001;59(3):1052–8. naturecom

    Article  CAS  PubMed  Google Scholar 

  14. Grady C. The cognitive neuroscience of ageing. Nat Rev Neurosci. 2012;13(7):491–505. nature.com

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Ruckh JM, Zhao J-W, Shadrach JL, van Wijngaarden P, Nageswara Rao T, Wagers AJ, Franklin RJM. Rejuvenation of regeneration in the aging central nervous system. Cell Stem Cell. 2012;10(1):96–103. Elsevier

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Wickremaratchi MM, Llewelyn JG. Effects of ageing on touch. Postgrad Med J. 2006;82(967):301–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Patterson KK, Nadkarni NK, Black SE, McIlroy WE. Gait symmetry and velocity differ in their relationship to age. Gait Posture. 2012;35(4):590–4. Elsevier

    Article  PubMed  PubMed Central  Google Scholar 

  18. Gabuzda D, Yankner BA. Physiology: inflammation links ageing to the brain. Nature. 2013;497(7448):197–8. nature.com

    Article  CAS  PubMed  Google Scholar 

  19. Szoke E, Shrayyef MZ, Messing S, Woerle HJ, Haeften TW v, Meyer C, AsiminaMitrakou WP, Gerich JE. Effect of Aging on glucose homeostasis: accelerated deterioration of β-cell function in individuals with impaired glucose tolerance. Diabetes Care. 2008;31(3):539–43.

    Article  CAS  PubMed  Google Scholar 

  20. Bremner AP, Feddema P, Leedman PJ, Brown SJ, Beilby JP, Lim EM, Wilson SG, O’Leary PC, Walsh JP. Age-related changes in thyroid function: a longitudinal study of a community-based cohort. J Clin Endocrinol Metab. 2012;97(5):1554–62. press.endocrine.org

    Article  CAS  PubMed  Google Scholar 

  21. Röck K, Tigges J, Sass S, Schütze A, Florea A-M, Fender AC, Theis FJ, et al. miR-23a-3p causes cellular senescence by targeting Hyaluronan synthase 2: possible implication for skin aging. J Invest Dermatol. 2015;135(2):369–77. naturecom

    Article  PubMed  Google Scholar 

  22. Toffanello ED, Inelmen EM, Imoscopi A, Perissinotto E, Coin A, Miotto F, Donini LM, et al. Taste loss in hospitalized multimorbid elderly subjects. Clin Interv Aging. 2013;8(February):167–74. ncbi.nlm.nih.gov

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Anantharaju A, Feller A, Chedid A. Aging liver. A review. Gerontology. 2002;48(6):343–53. karger.com

    Article  CAS  PubMed  Google Scholar 

  24. McLachlan AJ, Pont LG. Drug metabolism in older people—a key consideration in achieving optimal outcomes with medicines. J Gerontol A Biol Sci Med Sci. 2012;67A(2):175–80. biomedgerontology.oxfordjournals

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Eastern Health, Melbourne, VIC, Australia

    William Browne M.B.B.S., F.R.A.C.P.

  2. School of Medicine and Public Health, Newcastle, NSW, Australia

    Balakrishnan Kichu R. Nair AM, MBBS, MD (Newcastle)

Authors
  1. William Browne M.B.B.S., F.R.A.C.P.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Balakrishnan Kichu R. Nair AM, MBBS, MD (Newcastle)
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Balakrishnan Kichu R. Nair AM, MBBS, MD (Newcastle) .

Editor information

Editors and Affiliations

  1. School of Medicine and Public Health Hunter Health, John Hunter Campus, Newcastle, Australia

    Balakrishnan Kichu R. Nair

Rights and permissions

Reprints and permissions

Copyright information

© 2018 The Editor(s)

About this chapter

Cite this chapter

Browne, W., Nair, B.K.R. (2018). Physiology of Ageing. In: Nair, B. (eds) Geriatric Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-10-3253-0_2

Download citation

  • DOI: https://doi.org/10.1007/978-981-10-3253-0_2

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-3252-3

  • Online ISBN: 978-981-10-3253-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation