Physiological ageing is a complex process of progressive reduction in function that occurs in all organ systems. This process may be summarized in the expression “homeostenosis”.
Processes influencing ageing include gene variations and differences in expression and environmental factors. The interplay between these elements is not well understood.
Pathological processes have a major impact on the rate and character of organ changes with age that may not be readily distinguished from “physiological ageing”.
Tissues in all organ systems undergo changes with age including alterations in connective tissue makeup, cell numbers and neurohormonal signalling manifesting as reduced function.
Understanding the typical physiological changes of ageing improves a clinician’s ability to provide care to older patients.
KeywordsSirtuin 1 Gene Expression Major Physiological Alterations Aging-related Changes Altered Metabolic Rate Predicted Reduction
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