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Next Generation Devices and Technologies Through Regenerative Engineering

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Healthcare Engineering

Abstract

The next decade will see pioneering research to regenerate musculoskeletal tissues. This will enable us to move from an era of advanced prosthetics, to what is termed as “Regenerative Engineering” which aims to regenerate complex tissues and organ systems. The paper presents an overview of the regenerative toolbox under development to address grand challenges in musculoskeletal regeneration.

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References

  1. Deng M, James R, Laurencin CT, Kumbar SG. Nanostructured polymeric scaffolds for orthopaedic regenerative engineering. IEEE Trans. Nanobiosci. 11(1), 3–14 (2012).

    Google Scholar 

  2. Talmo CT, Aghazadeh M, Bono JV. Perioperative complications following total joint replacement. Clin. Geriatr. Med. 28(3), 471–487 (2012).

    Google Scholar 

  3. Khademhosseini A, Vacanti JP, Langer R. Progress in tissue engineering. Sci. Am. 300(5), 64–71 (2009).

    Google Scholar 

  4. Laurencin CT, Ambrosio AA, Borden MD, Cooper JA. Annual Review of Biomedical Engineering. Yarmush ML Ed (Annual Reviews, Palo Alto); 1999; pp. 19–46.

    Google Scholar 

  5. Laurencin CT, Khan Y. Regenerative Engineering, Sci Transl. Med 4, 160ed9 (2012).

    Google Scholar 

  6. Guerette PA, Hoon S, Seow Y, Raida M, Masic A, Wong FT, Ho VHB, Kong KW, Demirel MC, Francesch AP, Amini S, Tay GZ, Ding D, Miserez A, Accelerating the design of biomimetic materials by integrating RNA-seq with proteomics and materials science. Nature Biotechnology, 31: 908 (2013).

    Google Scholar 

  7. Reichert WM, Ratner BD, Anderson J, Coury A, Hoffman AS, Laurencin CT, Tirrell D. 2010 panel on the Biomaterials grand challenges. J Biomed Mater Res A. 96: 275 (2011).

    Google Scholar 

  8. Gardiner DM, Bryant S, Muneoka K. Engineering Limb regeneration: Lessons for Animals that can Regenerate. In Regenerative Engineering (Laurencin CT and Khan Y Eds). CRC Press, Talor & Francis (2013).

    Google Scholar 

  9. Nair LS, Khan Y, Laurencin CT. Polyphosphazenes. In Introduction to Biomaterials (Hollinger Ed). CRC press, Taylor & Francis (2012).

    Google Scholar 

  10. Deng M, Nair LS, Nukavarapu S, Kumbar SG, Jiang T, Weikel AL, Krogman NR, Allcock HR, Laurencin CT. In Situ porous structures: A unique polymer erosion mechanism biodegradable in biodegradable dipeptide-based polyphosphazene and polyester blends producing matrices for regenerative engineering. Adv. Funct. Mater 20: 2794 (2010).

    Google Scholar 

  11. Jabbarzadeh E, Starnes T, Khan Y, Jiang T, Wirtel AJ, Deng M, Lv Q, Nair LS, Doty SB, Laurencin CT. Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: A combined gene therapy and cell transplantation approach. PNAS, 105: 11099 (2008).

    Google Scholar 

  12. Kofron MD, Griswold A, Kumbar SG, Martin K, Wen X, Laurencin CT. The implications of polymer selection in regenerative medicine: A comparison of amorphous and semi-crystalline polymer for tissue regeneration. Adv Funct Mater 19: 1351 (2009).

    Google Scholar 

  13. http://www.globusmedical.com/microfuse-technology-engineered-for-optimal-strength-and-porosity/.

  14. Cooper JA, Lu HH, Ko FK, Freeman JW, Laurencin CT. Fiber based tissue engineered scaffold for ligament replacement: design considerations and in vitro evaluation. Biomaterials 26: 1523 (2005).

    Google Scholar 

  15. Cooper JA, Sahota JS, Gorum WJ, Carter J, Doty SB, Laurencin CT. Biomimetic Tissue-engineered anterior cruciate ligament replacement. PNAS. 104: 3049 (2007).

    Google Scholar 

  16. Laurencin CT, Walsh W, Bertolla N, Poggie R, Reilly J, Nair LS. An engineering solution to anterior cruciate ligament regeneration using a biodegradable and biomimetic matrix. ABJS, proceedings of the 2013 Association of Bone and Joint Surgeons meeting, Istanbul, Turkey, April (2013).

    Google Scholar 

  17. Mengsteab PY, Nair LS, Laurencin CT. The past, present and future of ligament regenerative engineering. Regen. Med. doi:10.2217/rme-2016-0125 (2016) (Epub ahead of Print).

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Acknowledgments

The work is supported by the NIH Directors Pioneer Award (DP1OD019349). Dr. Laurencin was also the recipient of Presidential Faculty Fellow Award from the National Science Foundation.

Author information

Authors and Affiliations

  1. Department of Orthopedic Surgery, Institute for Regenerative Engineering, the Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health, Farmington, CT, 06030, USA

    Cato T. Laurencin & Lakshmi S. Nair

  2. Department of Chemical and Biomolecular Engineering, Biomedical Engineering, Institute of Material Science, University of Connecticut, Storrs, CT, 06269, USA

    Cato T. Laurencin

  3. Department of Material Science and Engineering, Biomedical Engineering, Institute of Material Science, University of Connecticut, Storrs, CT, 06269, USA

    Cato T. Laurencin & Lakshmi S. Nair

  4. Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, USA

    Cato T. Laurencin

  5. The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health, Farmington, CT, USA

    Cato T. Laurencin

Authors
  1. Cato T. Laurencin
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  2. Lakshmi S. Nair
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Corresponding author

Correspondence to Cato T. Laurencin .

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Editors and Affiliations

  1. Indian National Academy of Engineering , Gurgaon, Haryana, India

    Rajeev Shorey

  2. Executive Director, Birla Institute of Scientific Research Executive Director, Jaipur, Rajasthan, India

    Purnendu Ghosh

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© 2017 Springer Nature Singapore Pte Ltd.

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Laurencin, C.T., Nair, L.S. (2017). Next Generation Devices and Technologies Through Regenerative Engineering. In: Shorey, R., Ghosh, P. (eds) Healthcare Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-10-3111-3_4

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  • DOI: https://doi.org/10.1007/978-981-10-3111-3_4

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-3110-6

  • Online ISBN: 978-981-10-3111-3

  • eBook Packages: EngineeringEngineering (R0)

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