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Interaction of Bone Marrow Stem Cells with Other Cells

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Bone marrow stem cell therapy for stroke

Abstract

Transplantation of bone marrow stem cells (BMSCs) as a regenerative cell replacement therapy for stroke holds great promise. However, the mechanisms underlying functional recovery after stroke remain unclear. Clearly, BMSCs benefit the neurological dysfunction in either direct or indirect methods through the interaction with other cells. In this chapter, we review the direct and indirect interactions of transplanted BMSCs with HSCs, immune cells, neural stem cells (NSCs), neurons, astrocytes, and endothelial cells for better understanding of the mechanisms underlying BMSC-mediated neurological function improvement after stroke.

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Authors and Affiliations

  1. Center for Neuroscience Discovery, Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA

    Hongxia Zhang, Shengwei Huang, Jiangnan Hu & Brian Wang

  2. Department of Pharmacology Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA

    Kunlin Jin

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  2. Shengwei Huang
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  3. Jiangnan Hu
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  4. Brian Wang
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  5. Kunlin Jin
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Corresponding author

Correspondence to Kunlin Jin .

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Editors and Affiliations

  1. Department of Pharmacology Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA

    Kunlin Jin

  2. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, Beijing, China

    Xunming Ji

  3. Department of Neurosurgery First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China

    Qichuan Zhuge

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© 2017 Springer Nature Singapore Pte Ltd.

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Zhang, H., Huang, S., Hu, J., Wang, B., Jin, K. (2017). Interaction of Bone Marrow Stem Cells with Other Cells. In: Jin, K., Ji, X., Zhuge, Q. (eds) Bone marrow stem cell therapy for stroke. Springer, Singapore. https://doi.org/10.1007/978-981-10-2929-5_4

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