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Autologous Bone Marrow Mononuclear Cell Implantation in Extremities with Critical Limb Ischemia

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Therapeutic Angiogenesis

Abstract

Critical limb ischemia (CLI) is a terminal stage of peripheral artery disease (PAD), and the number of patients diagnosed with this condition is on the rise. CLI exerts a major impact on the patient’s quality of life and has poor prognosis. The number of CLI cases showing resistance to existing treatments (medical therapy, percutaneous transluminal angioplasty, and surgical bypass) is also increasing. Many of these cases lead to exacerbation of the ischemia and subsequent lower-limb amputation. To treat these patients, cell-based angiogenesis is becoming an attractive new strategy. Cell-based therapy has also been used to treat ischemic myocardium. Bone marrow cells possess the ability to differentiate into various tissue types and can thus regenerate the myocardium by inducing angiogenesis and myogenesis, as shown by recent accumulating evidence reporting improved cardiac function and myocardial perfusion in animals and humans. Therapeutic angiogenesis with autologous bone marrow mononuclear cells (BMMNCs) is a term that has become widely used in the last decade. The safety and efficacy of therapeutic angiogenesis using autologous BMMNCs have been supported by clinical studies and meta-analyses.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan

    Kenji Yanishi M.D. & Satoaki Matoba M.D., Ph.D.

Authors
  1. Kenji Yanishi M.D.
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  2. Satoaki Matoba M.D., Ph.D.
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Corresponding author

Correspondence to Kenji Yanishi M.D. .

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Editors and Affiliations

  1. Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan

    Yukihito Higashi

  2. Department of Cardiology, Nagoya University, Aichi, Japan

    Toyoaki Murohara

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© 2017 Springer Nature Singapore Pte Ltd.

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Yanishi, K., Matoba, S. (2017). Autologous Bone Marrow Mononuclear Cell Implantation in Extremities with Critical Limb Ischemia. In: Higashi, Y., Murohara, T. (eds) Therapeutic Angiogenesis. Springer, Singapore. https://doi.org/10.1007/978-981-10-2744-4_2

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  • DOI: https://doi.org/10.1007/978-981-10-2744-4_2

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-2743-7

  • Online ISBN: 978-981-10-2744-4

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