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Urethra

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Clinical Regenerative Medicine in Urology

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Abstract

Replacing urethral tissue with functional scaffolds has been one of the challenges in the field of urethral reconstruction or repair over the last few decades. Various scaffold materials have been used in animal studies, but clinical studies in the use of scaffolds for urethral repair are scarce. It was found that in both animal and clinical studies, scaffolds seeded with cells were used for repair of large segmental defects of the urethra, such as in tubular urethroplasty. When the defect area was small, cell-free scaffolds were more likely to be applied. A large amount of pre-clinical and limited clinical evidence showed that natural or artificial materials could be used as scaffolds for urethral repair. Urinary tissue engineering is still in the immature stage, and the safety, efficacy, and cost-effectiveness of scaffolds must be evaluated to allow further study.

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  1. Department of Urology, School of Medicine, Kyungpook National University, Daegu, South Korea

    Yun-Sok Ha & Tae-Hwan Kim

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  1. Department of Urology, Kyungpook National University Hospital, Daegu, Korea (Republic of)

    Bup Wan Kim

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Ha, YS., Kim, TH. (2018). Urethra. In: Kim, B. (eds) Clinical Regenerative Medicine in Urology. Springer, Singapore. https://doi.org/10.1007/978-981-10-2723-9_9

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