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Chemoprevention by Genistein

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Cancer and Chemoprevention: An Overview

Abstract

Genistein (4,5,7-trihydroxyisoflavone) is a typical example of a phytoestrogenic compound, polyphenolic isoflavone, found in soy products, obtained primarily from Genista tinctoria L. in 1899 and named after the genus of this plant. Genistein is synthesized through transfer of (2S)-naringin into genistein by NAD(P)H in aerobic conditions and in the presence of cytochrome P450 in soybean cell suspension cultures (Kochs and Grisebach 1986). Furthermore, a metabolic engineering strategy to synthesize genistein was initiated by using genetically engineered Saccharomyces cerevisiae yeast cells having isoflavone synthase (IFS) gene obtained from Glycyrrhiza echinata L. (Koopman et al. 2012). Likewise, genistein was formed in Nicotiana tabacum L. leaves transformed with IFS by acting at phenylpropanoid pathway, although genistein production was enhanced by UVB treatment in Arabidopsis (Oliver et al. 2000).

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  1. Department of Toxicology, Jamia Hamdard, New Delhi, India

    Summya Rashid

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Rashid, S. (2017). Chemoprevention by Genistein. In: Cancer and Chemoprevention: An Overview. Springer, Singapore. https://doi.org/10.1007/978-981-10-2579-2_17

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