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Chemoprevention by Resveratrol

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Cancer and Chemoprevention: An Overview
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Abstract

Resveratrol is a naturally occurring polyphenol found abundantly in red grapes and red wine. It has been found to be antioxidant, anti-inflammatory, anti-carcinogenic, and antibacterial from the extensive research during the last two decades. It modulates various multiple biological pathways and hence exerts its chemopreventive and chemotherapeutic effects (Chung et al. 2013).

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References

  • Aziz MH, Afaq F, Ahmad N et al (2005) Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin. Photochem Photobiol 81:25–31

    Article  CAS  PubMed  Google Scholar 

  • Banerjee S, Bueso-Ramos C, Aggarwal BB (2002) Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor kappa B, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 62:4945–4954

    CAS  PubMed  Google Scholar 

  • Bhat KPL, Lantvit D, Christov K et al (2001) Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res 61:7456–7463

    CAS  PubMed  Google Scholar 

  • Bishayee A, Barnes KF, Bhatia D et al (2010) Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis. Cancer Prev Res 3:753–763

    Article  CAS  Google Scholar 

  • Brown VA, Patel KR, Viskaduraki M et al (2010) Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res 70:9003–9011

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carb’o N, Costelli P, Baccino FM et al (1999) Resveratrol, a natural product present in wine,decreases tumour growth in a rat tumour model. Biochem Biophys Res Commun 254:739–743

    Article  Google Scholar 

  • Chung MY, Lim TG, Lee KW (2013) Molecular mechanisms of chemopreventive phytochemicals against gastroenterological cancer development. World J Gastroenterol 19:984–993

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Garvin S, Ollinger K, Dabrosin C (2006) Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer Lett 231(113–122):2006

    Google Scholar 

  • Harper CE, Patel BB, Wang J et al (2007) Resveratrol suppresses prostate cancer progression in transgenic mice. Carcinogenesis 28:946–1953

    Article  Google Scholar 

  • Kalra N, Roy P, Prasad S et al (2008) Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis. Life Sci 82:348–358

    Article  CAS  PubMed  Google Scholar 

  • Kimura Y, Okuda H (2001) Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in lewis lung carcinoma-bearing mice. J Nutr 131:1844–1849

    CAS  PubMed  Google Scholar 

  • Lee EO, Lee HJ, Hwang HS et al (2006) Potent inhibition of Lewis lung cancer growth by heyneanol A from the roots of Vitis amurensis through apoptotic and anti-angiogenic activities. Carcinogenesis 27:2059–2069

    Article  CAS  PubMed  Google Scholar 

  • Lin HC, Chen YF, Hsu WH et al (2012) Resveratrol helps recovery from fatty liver and protects against hepatocellular carcinoma induced by hepatitis B virus X protein in a mouse model. Cancer Prev Res (Phila) 5:952–962

    Article  CAS  Google Scholar 

  • Liu P, Liang H, Xia Q et al (2013) Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR-21 regulation of BCL- 2 expression. Clin Transl Oncol 15:741–746

    Article  CAS  PubMed  Google Scholar 

  • Luo H, Wang L, Schulte BA et al (2013) Resveratrol enhances ionizing radiation-induced premature senescence in lung cancer cells. Int J Oncol 43:1999–2006

    CAS  PubMed  PubMed Central  Google Scholar 

  • Malhotra A, Bath S, Elbarbry F (2015) An organ system approach to explore the antioxidative, anti-inflammatory, and cytoprotective actions of resveratrol. Oxid Med Cell Longev 2015:803971

    Article  PubMed  PubMed Central  Google Scholar 

  • Nguyen AV, Martinez M, Stamos MJ et al (2009) Results of a phase I pilot clinical trial examining the effect of plant derived resveratrol and grape powder on wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res 1:25–37

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Oi N, Jeong CH, Nadas J et al (2010) Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A(4) hydrolase. Cancer Res 70:9755–9764

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Popat R, Plesner T, Davies F et al (2013) A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma. Br J Haematol 160:714–717

    Article  CAS  PubMed  Google Scholar 

  • Provinciali M, Re F, Donnini A et al (2005) Effect of resveratrol on the development of spontaneous mammary tumors in HER- 2/neu transgenic mice. Int J Cancer 115:36–45

    Article  CAS  PubMed  Google Scholar 

  • Roy SK, Chen Q, Fu J et al (2011) Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors. PLoS One 6:e25166

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schneider Y, Duranton B, Goss’e F et al (2001) Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis. Nutr Cancer 39:102–107

    Article  CAS  PubMed  Google Scholar 

  • Seeni A, Takahashi S, Takeshita K et al (2008) Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model. Asian Pac J Cancer Prev 9:7–14

    PubMed  Google Scholar 

  • Soleas GJ, Grass L, Josephy PD et al (2002) A comparison of the anticarcinogenic properties of four red wine polyphenols. Clin Biochem 35:119–124

    Article  CAS  PubMed  Google Scholar 

  • Tessitore L, Davit A, Sarotto I et al (2000) Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression. Carcinogenesis 21:1619–1622

    Article  CAS  PubMed  Google Scholar 

  • Wu SL, Sun ZJ, Yu L et al (2004) Effect of resveratrol and in combination with 5-FU on murine liver cancer. World J Gastroenterol 10:3048–3052

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhou HB, Chen JJ, Wang WX et al (2005) Anticancer activity of resveratrol on implanted human primary gastric carcinoma cells in nude mice. World J Gastroenterol 11:280–284

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Rashid, S. (2017). Chemoprevention by Resveratrol. In: Cancer and Chemoprevention: An Overview. Springer, Singapore. https://doi.org/10.1007/978-981-10-2579-2_16

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