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Heterologous Protein Expression in the Aspergilli: Overcoming Obstacles in the Secretory Pathway

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Book cover Microbial Models: From Environmental to Industrial Sustainability

Part of the book series: Microorganisms for Sustainability ((MICRO,volume 1))

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Abstract

Some Aspergillus species are widely used as cell factories for the production of heterologous proteins, showing, among other advantages, an exceptional secretion capacity. Due to the complexity of the translation and maturation of secretory proteins, several bottlenecks in this process are at the basis of low product yields. In this work, we review the most recent strategies aiming to improve the use of the aspergilli for recombinant protein production, centering on those which target the translation and secretion process.

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  1. Biochemistry and Molecular Biology Section, Faculty of Sciences, Universidad de la República, Igua 4225, Montevideo, Uruguay

    Manuel Sanguinetti & Ana Ramón

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  1. Biochemistry and Molecular Biology Section, Faculty of Sciences, Universidad de la República, Montevideo, Uruguay

    Susana Castro-Sowinski

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Sanguinetti, M., Ramón, A. (2016). Heterologous Protein Expression in the Aspergilli: Overcoming Obstacles in the Secretory Pathway. In: Castro-Sowinski, S. (eds) Microbial Models: From Environmental to Industrial Sustainability. Microorganisms for Sustainability, vol 1. Springer, Singapore. https://doi.org/10.1007/978-981-10-2555-6_7

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