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Insect Proteases: Structural-Functional Outlook

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Proteases in Physiology and Pathology

Abstract

Proteases perform various activation and effector functions in development, growth, and survival in insects. In this chapter, we have focused on the catalogue of insect proteases and their structural and functional aspects. We have reviewed the proteases involved in insect’s vital life processes like reproduction, development, immunity, and defence. The indispensability of seminal fluid and egg protease during fertilization highlights their evolutionary primitiveness. Furthermore, various cellular proteases like cathepsins and caspases take over the earlier one’s functions. The role of cellular proteases is well documented in the developmental process like embryogenesis, metamorphosis, moulting, and eclosion. Cellular proteases are further supported by haemolymph and digestive proteases to facilitate the growth and survival of the insect. Apart from developmental cathepsin and caspases, haemolymph contains a diverse pool of proteases that serves a pivotal role in immunity against various pathogens. Amongst various insect proteases, digestive proteases show highest structural and functional variability according to developmental stage, food content and stress level. This chapter provides an insight of structural-functional aspects of insect proteases and their role in insect physiology.

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Acknowledgements

Funding under the Divisional Research and Development Program (DRDP) to the Institute of Bioinformatics and Biotechnology, Savitribai Phule Pune University, Pune, India, is greatly acknowledged. Dr. Sneha acknowledges the Royal Society, UK, for its financial support under the Newton International Fellowship scheme. Editorial assistance by Mr. Aniruddha Agnihotri and Ms. Shriya Lele is highly acknowledged. The authors declare no conflict of interest.

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Authors and Affiliations

  1. Institute of Bioinformatics and Biotechnology, Savitribai Phule Pune University (Formerly University of Pune), Pune, 411007, Maharashtra, India

    Shounak Jagdale & Rakesh Joshi

  2. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

    Sneha Bansode

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  1. Shounak Jagdale
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  2. Sneha Bansode
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  3. Rakesh Joshi
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Correspondence to Rakesh Joshi .

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  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. St. Boniface Hospital Research Centre, University of Manitoba, Faculty of Health Sciences, College of Medicine, Institute of Cardiovascular Sciences, Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla

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Jagdale, S., Bansode, S., Joshi, R. (2017). Insect Proteases: Structural-Functional Outlook. In: Chakraborti, S., Dhalla, N. (eds) Proteases in Physiology and Pathology. Springer, Singapore. https://doi.org/10.1007/978-981-10-2513-6_21

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