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Physiological and Pathological Functions of Mitochondrial Proteases

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Proteases in Physiology and Pathology

Abstract

Mitoproteases display an essential role in the preservation of mitochondrial homeostasis under regular and stress conditions. These enzymes perform tightly regulated proteolytic reactions by which they participate in mitochondrial protein trafficking, processing and activation of proteins, protein quality control, regulation of mitochondrial biogenesis, control of mitochondrial dynamics, mitophagy, and apoptosis. In this chapter, we have revised the physiological functions of the intrinsic mitochondrial proteases, analyzing their roles in the different compartments of this organelle and their connection to human pathology, primarily cancer, neurodegenerative disorders, and multisystemic diseases.

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Acknowledgments

The work in our laboratory was supported by grants from Ministerio de Economía y Competitividad and Instituto de Salud Carlos III (RTICC). We also thank the generous support by J.I. Cabrera. The Instituto Universitario de Oncología is supported by Fundación Bancaria Caja de Ahorros de Asturias.

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  1. Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006, Oviedo, Spain

    Clea Bárcena, Pablo Mayoral, Pedro M. Quirós & Carlos López-Otín

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  1. Clea Bárcena
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  2. Pablo Mayoral
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  3. Pedro M. Quirós
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Correspondence to Carlos López-Otín .

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  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. St. Boniface Hospital Research Centre, University of Manitoba, Faculty of Health Sciences, College of Medicine, Institute of Cardiovascular Sciences, Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla

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Bárcena, C., Mayoral, P., Quirós, P.M., López-Otín, C. (2017). Physiological and Pathological Functions of Mitochondrial Proteases. In: Chakraborti, S., Dhalla, N. (eds) Proteases in Physiology and Pathology. Springer, Singapore. https://doi.org/10.1007/978-981-10-2513-6_1

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