Skip to main content
SpringerLink
Log in

Media-Responsive Swelling and Material Release Properties of Polysaccharide Composite Films

  • Chapter
  • First Online:
Stimuli-Responsive Interfaces

  • 615 Accesses

Abstract

Free-standing, water-insoluble thin films made of polyion complexes of natural polysaccharides, for example, chondroitin sulfate and chitosan, are successfully obtained by utilizing hot press techniques. These films exhibit sufficient mechanical properties to be used as structural materials in the dry state. On the other hand, the films swell to some extent and soften in water, but are not dissolved out, although they are made of water-soluble polysaccharides. The degree of swelling is controllable depending on the species and pH of the media, in addition to the polysaccharide species. When small dye molecules are used as model drugs, dye-loaded films are obtained using both pre- and post-loading methods. These dye-loaded films release the dye molecules when immersed in aqueous media. The kinetics of the dye release is affected by the species and pH of the solutions, which indicate that it is correlated with the swelling behavior of the films. These results support that the free-standing polysaccharide composite films have promise to be used as biocompatible film materials such as plasters or wound dressings having media-responsive drug release abilities.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Stuart MAC, Huck WTS, Genzer J, Muller M, Ober C, Stamm M, Sukhorukov GB, Szleifer I, Tsukruk VV, Urban M, Winnik F, Zauscher S, Luzinov I, Minko S (2010) Emerging applications of stimuli-responsive polymer materials. Nat Mater 9:101–113

    Article  Google Scholar 

  2. Theato P, Sumerlin BS, O’Reilly RK, Epps III TH (eds) (2013) Stimuli responsive themed issue. Chem Soc Rev 42(17):7045–7486

    Google Scholar 

  3. Ganesh VA, Baji A, Ramakrishna S (2014) Smart functional polymers—a new route towards creating a sustainable environment. RSC Adv 4:53352–53364

    Article  Google Scholar 

  4. Guragain S, Bastakoti BP, Malgras V, Nakashima K, Yamauchi Y (2015) Multi-stimuli-responsive polymeric materials. Chem Eur J 21:13164–13174

    Article  Google Scholar 

  5. Chen JK, Chang CJ (2014) Fabrications and applications of stimulus-responsive polymer films and patterns on surfaces: a review. Materials 7:805–875

    Article  Google Scholar 

  6. Meng H, Li G (2013) A review of stimuli-responsive shape memory polymer composites. Polymer 54:2199–2221

    Article  Google Scholar 

  7. Ganta S, Devalapally H, Shahiwala A, Amiji M (2008) A review of stimuli-responsive nanocarriers for drug and gene delivery. J Controlled Release 126:187–204

    Article  Google Scholar 

  8. Molina M, Asadian-Birjand M, Balach J, Bergueiro J, Miceli E, Calderón M (2015) Stimuli-responsive nanogel composites and their application in nanomedicine. Chem Soc Rev 44:6161–6186

    Article  Google Scholar 

  9. Rinaudo M (2008) Main properties and current applications of some polysaccharides as biomaterials. Polym Int 57:397–430

    Article  Google Scholar 

  10. Iijima K, Hashizume M (2015) Application of polysaccharides as structural materials. Trends Glycosci Glycotechnol 27:67–79

    Article  Google Scholar 

  11. Czaja WK, Young DJ, Kawecki M, Brown RM Jr (2007) The future prospects of microbial cellulose in biomedical applications. Biomacromolecules 8:1–12

    Article  Google Scholar 

  12. Ravi Kumer MNV, Muzzarelli RAA, Muzzarelli C, Sashiwa H, Domb AJ (2004) Chitosan chemistry and pharmaceutical perspectives. Chem Rev 104:6017–6084

    Article  Google Scholar 

  13. Hashizume M, Kobayashi H, Ohashi M (2011) Preparation of free-standing films of natural polysaccharides using hot press technique and their surface functionalization with biomimetic apatite. Colloids Surf B 88:534–538

    Article  Google Scholar 

  14. Hashizume M, Ohashi M, Kobayashi H, Tsuji Y, Iijima K (2015) Preparation of free-standing polysaccharide composite films: improved preparation and physical properties. Colloids Surf A 483:18–24

    Article  Google Scholar 

  15. Sintov A, Di-Capua N, Rubinstein A (1995) Cross-linked chondroitin sulphate: characterization for drug delivery purposes. Biomaterials 16:473–478

    Article  Google Scholar 

  16. Kubo K, Kuroyanagi Y (2004) Development of cultured dermal substitute composed of a spongy matrix of hyaluronic acid and atelo-collagen combined with fibroblasts: cryopreservation. Artif Organs 28:182–188

    Article  Google Scholar 

  17. Vercruysse KP, Marecak DM, Marecek JF, Prestwich GD (1997) Synthesis and in vitro degradation of new polyvalent hydrazide cross-linked hydrogels of hyaluronic acid. Bioconjugate Chem 8:686–694

    Article  Google Scholar 

  18. Luo Y, Kirker KR, Prestwich GD (2000) Cross-linked hyaluronic acid hydrogel films: new biomaterials for drug delivery. J Controlled Release 69:169–184

    Article  Google Scholar 

  19. Hunt JA, Joshi HN, Stella VJ, Topp EM (1990) Diffusion and drug release in polymer films prepared from ester derivatives of hyaluronic acid. J Controlled Release 12:159–169

    Article  Google Scholar 

  20. Campoccia D, Doherty P, Radice M, Brun P, Abatangelo G, Williams DF (1998) Semisynthetic resorbable materials from hyaluronan esterification. Biomaterials 19:2101–2127

    Article  Google Scholar 

  21. Chen WB, Wang LF, Chen JS, Fan SY (2005) Characterization of polyelectrolyte complexes between chondroitin sulfate and chitosan in the solid state. J Biomed Mater Res 75A:128–137

    Article  Google Scholar 

  22. Kikuchi Y, Noda A (1976) Polyelectrolyte complexes of heparin and chitosan. J Appl Polym Sci 20:2561–2563

    Article  Google Scholar 

  23. Peniche C, Fernández M, Rodríguez G, Parra J, Jimenez J, López Bravo A, Gómez D, San Román J (2007) Cell supports of chitosan/hyaluronic acid and chondroitin sulphate system. Morphology and biological behaviour. J Mater Sci Mater Med 18:1719–1726

    Article  Google Scholar 

  24. Meng X, Tian F, Yang J, He CN, Xing N, Li F (2010) Chitosan and alginate polyelectrolyte complex membranes and their properties for wound dressing application. J Mater Sci Mater Med 21:1751–1759

    Article  Google Scholar 

  25. Fajardo AR, Lopes LC, Valente AJM, Rubira AF, Muniz EC (2011) Effect of stoichiometry and pH on the structure and properties of chitosan/chondroitin sulfate complexes. Colloid Polym Sci 289:1739–1748

    Article  Google Scholar 

  26. Decher G (1997) Fuzzy nanoassemblies: toward layered polymeric multicomponents. Science 277:1232–1237

    Article  Google Scholar 

  27. Decher G, Schlenoff JB (eds) (2012) Multilayer thin films, 2nd edn. Wiley-VCH, Weinheim

    Google Scholar 

  28. Ariga K, Yamauchi Y, Rydzek G, Ji Q, Yonamine Y, Wu KCW, Hill JP (2013) Layer-by-layer nanoarchitectonics: invention, innovation, and evolution. Chem Lett 43:36–68

    Article  Google Scholar 

  29. Fujie T, Okamura Y, Takeoka S (2007) Ubiquitous transference of a free-standing polysaccharide nanosheet with the development of a nano-adhesive plaster. Adv Mater 19:3549–3553

    Article  Google Scholar 

  30. Iijima K, Yuyama K, Asaine K, Irie K, Hashizume M (2014) Preparation of chondroitin sulfate/chitosan composite fibers by spinning from aqueous solution interfaces. Kobunshi Ronbunshu 71:11–16

    Article  Google Scholar 

  31. Larsson B, Nilson M, Tjälve H (1981) The binding of inorganic and organic cations and H+ to cartilage in vitro. Biochem Pharmacol 30:2963–2970

    Article  Google Scholar 

  32. Scordilis-Kelley C, Osteryoung JG (1996) Voltammetric studies of counterion transport in solutions of chondroitin sulfate. J Phys Chem 100:797–804

    Article  Google Scholar 

  33. Domard A (1987) pH and c.d. measurements on a fully deacetylated chitosan: application to CuII–polymer interactions. Int J Biol Macromol 9:98–104

    Article  Google Scholar 

  34. Hashizume M, Murata Y, Iijima K, Shibata T (2016) Drug loading and release behaviors of freestanding polysaccharide composite films. Polymer J 48:545–550

    Article  Google Scholar 

  35. Chen JX, Wang M, Tian HH, Chen JH (2015) Hyaluronic acid and polyethyleneimine self-assembled polyion complexes as pH-sensitive drug carrier for cancer therapy. Colloids Surf B 134:81–87

    Article  Google Scholar 

Download references

Acknowledgments

This work was partly supported by JSPS KAKENHI Grant Numbers 22550155, 25410178, and a grant from The Association for the Progress of New Chemistry (ASPRONC), Japan.

Author information

Authors and Affiliations

  1. Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Tokyo, Japan

    Mineo Hashizume & Kazutoshi Iijima

Authors
  1. Mineo Hashizume
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kazutoshi Iijima
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mineo Hashizume .

Editor information

Editors and Affiliations

  1. Tokyo University of Science, Tokyo, Japan

    Takeshi Kawai

  2. Tokyo University of Science, Tokyo, Japan

    Mineo Hashizume

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Nature Singapore Pte Ltd.

About this chapter

Cite this chapter

Hashizume, M., Iijima, K. (2017). Media-Responsive Swelling and Material Release Properties of Polysaccharide Composite Films. In: Kawai, T., Hashizume, M. (eds) Stimuli-Responsive Interfaces. Springer, Singapore. https://doi.org/10.1007/978-981-10-2463-4_15

Download citation

Publish with us

Policies and ethics

Search

Navigation