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Insulin-like Growth Factor-1 and Its Related Signalling During Aging: Modulation by Dietary Restriction

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Topics in Biomedical Gerontology

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Abstract

Aging is characterized as the changes of several biological processes in an organism as a function of time. The most important system engaged during the aging process is the endocrine system. Insulin-like growth factor-1(IGF-1), a single chain polypeptide synthesized under the action of growth hormone (GH), regulates a variety of developmental and metabolic processes of an organism. The primary source of serum IGF-1 is the liver; however, it is also synthesized in other tissues where it functions as autocrine and paracrine hormone. It acts by binding to its cell surface receptor and amplifies its action by regulating downstream molecules like PI3K, Akt, SIRT, FOXO, NF-ĸB, thereby, forming a network of signalling pathways. The link of IGF-1 and its signalling pathway to the process of aging is of significant interest because it is involved in controlling various cellular processes that determine the lifespan of an organism. Dietary restriction (DR), an intervention where the intake of food is lessened but without causing any malnourishment, has been found to be an effective modulator of the IGF-1 signalling pathway. An outline of IGF-1 and its signalling pathway in aging process and how DR acts as a mediator of various players of the pathway that may enhance longevity in various model organisms will be illustrated.

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Acknowledgments

The authors thank UGC-DRS, DST-FIST, DBT infrastructure and Biochemistry Department of North-Eastern Hill University, Shillong for the research funds and facilities. IKH Hadem is thankful to CSIR (Council of Scientific and Industrial Research), New Delhi for providing financial assistant as junior/senior research fellowships (09/347(0189)/2010-EMR-1).

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  1. Biochemistry Department, North-Eastern Hill University, Shillong, 793022, India

    Ibanylla Kynjai Hynniewta Hadem & Ramesh Sharma

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  1. Ibanylla Kynjai Hynniewta Hadem
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  2. Ramesh Sharma
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Correspondence to Ramesh Sharma .

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  1. School of Life Sciences, Molecular Biology Laboratory, Jawaharlal Nehru University, New Delhi, Delhi, India

    Pramod C. Rath

  2. Department of Biochemistry, North Eastern Hill University, Shillong, Megalaya, India

    Ramesh Sharma

  3. Biochemistry & Molecular Biology Lab, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    S. Prasad

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Hadem, I.K.H., Sharma, R. (2017). Insulin-like Growth Factor-1 and Its Related Signalling During Aging: Modulation by Dietary Restriction. In: Rath, P., Sharma, R., Prasad, S. (eds) Topics in Biomedical Gerontology. Springer, Singapore. https://doi.org/10.1007/978-981-10-2155-8_5

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