Morphology of the Human Pancreas During Development and Aging

  • Renu Gupta
  • Shubhi Saini
  • Saroj Sharma
  • Tony G. Jacob
  • T. S. Roy


Pancreas gets affected by fibrosis associated with aging. This study analyzed the age-related fibrotic changes in the ductular system of the pancreas. After obtaining necessary ethical clearances, twelve human fetal and thirty post-natal and adult pancreas were collected and processed to obtain resin-embedded sections for transmission electron microscopy and paraffin-embedded sections for H&E staining and light microscopy. The sections were analyzed qualitatively and quantitatively. The human pancreas had mature zymogen granules in the exocrine part and secretory granules in the endocrine part by 20th week of gestation. The amount of connective tissue and acini increased with age. After the 3rd decade, there was increased fibrosis. This began around small and medium sized ducts. Changes in the epithelium of ducts were seen in later decades. There was a direct correlation between area of the ducts and increasing age. There was increased fibrosis in and around the islets of Langerhans. The number of fibroblasts and stellate cells increased with age. The increased fibrosis with increasing age that first appears around the small and medium sized ducts may be due to increased number of pancreatic stellate cells.


Stellate cells Zymogen granules Islets of langerhans Fibrosis Nucleator Transmission electron microscopy 

Supplementary material

385338_1_En_4_MOESM1_ESM.tif (297 kb)
Suppl. Fig. 1Electronmicrograph of a pancreatic ductal cell displaying a monocilium on its luminal surfaceSupplementary material 1 (TIFF 296 kb)


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Copyright information

© Springer Science+Business Media Singapore 2017

Authors and Affiliations

  • Renu Gupta
    • 1
  • Shubhi Saini
    • 2
  • Saroj Sharma
    • 3
  • Tony G. Jacob
    • 2
  • T. S. Roy
    • 4
  1. 1.Department of AnatomyAll India Institute of Medical SciencesJodhpurIndia
  2. 2.Department of AnatomyAll India Institute of Medical SciencesNew DelhiIndia
  3. 3.Dr. B.S. Ambedkar Medical College and HospitalDelhiIndia
  4. 4.Department of AnatomyAll India Institute of Medical SciencesNew DelhiIndia

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