Conclusion and Clinical Decision Algorithm



We have conducted a systematic qualitative review on the pharmacokinetic and pharmacodynamic drug-drug interactions associated with antiretroviral drugs currently recommended by the World Health Organization. The limitations and future directions have been provided in each Chapter Summary. Here, we will present a Clinical Decision Algorithm (modified from a previous algorithm for antimalarials) [1] to help clinicians assess the relevance of identified drug-drug interactions associated with antiretroviral agents.


Antiviral Agent Human Liver Microsome Integrase Inhibitor Pharmacokinetic Drug Interaction Fusion Inhibitor 
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  1. 1.
    Kiang TKL, Wilby KJ, Ensom MHH (2015) Clinical pharmacokinetic and pharmacodynamic drug interactions associated with antimalarials. Springer International Publishing AG, Cham. doi: 10.1007/978-3-319-10527-7 (eBook). ISBN 978-3-319-10527-7Google Scholar

Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  1. 1.Faculty of Pharmaceutical SciencesThe University of British ColumbiaVancouverCanada
  2. 2.College of PharmacyQatar UniversityDohaQatar

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