Clinical Drug-Drug Interaction Data: Effects of Co-administered Drugs on Pharmacokinetics of Antiretroviral Agents



This chapter summarizes the clinical drug-drug interaction data for each antiretroviral agent. The effects of co-administered drugs on the pharmacokinetics of the following agents will be presented:
  • Nonnucleoside reverse transcriptase inhibitors (NNRTIs): delavirdine, efavirenz, etravirine, nevirapine, and rilpivirine

  • Nucleoside reverse-transcriptase inhibitors (NRTIs): abacavir, didanosine, and zidovudine

  • Protease inhibitors (PIs): atazanavir, darunavir, fosamprenavir, emtricitabine, lamivudine, stavudine, tenofovir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir, and lopinavir

  • Fusion Inhibitors: enfuvirtide

  • Entry inhibitors: maraviroc

  • Integrase inhibitors: dolutegravir, elvitegravir, raltegravir


Pharmacokinetic Interaction CYP450 Enzyme Tenofovir Disoproxil Fumarate CYP3A4 Inhibitor CYP3A4 Inducer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  1. 1.Faculty of Pharmaceutical SciencesThe University of British ColumbiaVancouverCanada
  2. 2.College of PharmacyQatar UniversityDohaQatar

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