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Pharmacology and Pharmacokinetic Properties of Available Antiretrovirals

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Abstract

Currently recommended antiretrovirals consist of a variety of agents from different drug classes. Differences in mechanism of action result in unique combinations that allow for additive interactions and synergy, leading to increased therapeutic success. However, overlapping toxicities place patients at risk of increased adverse effects such as hepatotoxicity and endocrine abnormalities. A summary of the pharmacological and pharmacokinetic considerations is given in Table 3.1 for currently available nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, protease inhibitors, entry inhibitors, fusion inhibitors, integrase inhibitors, and pharmacokinetic enhancers.

Keywords

Adverse Effect Infectious Disease Protease Inhibitor Reverse Transcriptase Pharmacokinetic Property 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  1. 1.College of PharmacyQatar UniversityDohaQatar
  2. 2.Faculty of Pharmaceutical SciencesThe University of British ColumbiaVancouverCanada

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