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Introduction

Chapter
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Abstract

This chapter will provide an overview of epidemiology, diagnosis, and treatment of the human immunodeficiency virus (HIV). A detailed description of the HIV lifecycle and identification of targets for antiretroviral therapy are also given.

Keywords

Human Immunodeficiency Virus Acquire Immune Deficiency Syndrome Male Circumcision Human Immunodeficiency Virus Transmission Human Immunodeficiency Virus Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Piot P, Bartos M, Ghys PD, Walker N, Schwartlander B (2001) The global impact of HIV/AIDS. Nature 410(6831):968–973CrossRefPubMedGoogle Scholar
  2. 2.
    Foster G, Williamson J (2000) A review of current literature of the impact of HIV/AIDS on children in sub-Saharan Africa. AIDS 14(Suppl 3):S275–284PubMedGoogle Scholar
  3. 3.
    Dixon S, McDonald S, Roberts J (2002) The impact of HIV and AIDS on Africa’s economic development. BMJ 324(7331):232–234BCrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Maartens G, Celum C, Lewin SR (2014) HIV infection: epidemiology, pathogenesis, treatment, and prevention. Lancet 384(9939):258–271CrossRefPubMedGoogle Scholar
  5. 5.
    U.S. Department of Health & Human Services. Global Statistics. 2015. Available at https://www.aids.gov/hiv-aids-basics/hiv-aids-101/global-statistics/. Accessed 18 June 2016
  6. 6.
    AIDSinfo. HIV overview: the HIV lifecycle. Updated Sep 22, 2015. Available from: https://aidsinfo.nih.gov/education-materials/fact-sheets/19/73/the-hiv-life-cycle# . Accessed 14 June 2016.
  7. 7.
    Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F et al (2000) Viral load and heterosexual transmission of human immunodeficiency virus type 1: Rakai Project Study Group. N Eng J Med 342(13):921–929CrossRefGoogle Scholar
  8. 8.
    Broeckaert L, Challacombe L. Rapid point-of-care HIV testing: a review of the evidence. Prevention in Focus 2015. Available from: http://www.catie.ca/en/pif/spring-2015/rapid-point-care-hiv-testing-review-evidence. Accessed 19 June 2016
  9. 9.
    Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1 infected adults and adolescents. Department of Health and Human Services. 2016. Available at http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf. Accessed 15 June 2016
  10. 10.
    Centers for Disease Control and Prevention (CDC) and Association of Public Health Laboratories. Laboratory testing for the diagnosis of HIV infection: updated recommendations. Published June 27, 2014. Available at http://dx.doi.org/10/15620/cdc.23447. Accessed 14 June 2016
  11. 11.
    INSIGHT START Study Group, Lundgren JD, Babiker AG, Gordin F, Emery S, Grund B et al (2015) Initiation of antiretroviral therapy in early asymptomatic HIV infection. N Engl J Med 373(9):795–807CrossRefGoogle Scholar
  12. 12.
    TEMPRANO ANRS 12136 Study Group, Danel C, Moh R, Gabillard D, Badje A, Le Carrou J et al (2015) A trial of early antiretroviral and isoniazid preventive therapy in Africa. N Engl J Med 373(9):808–822CrossRefGoogle Scholar
  13. 13.
    Trotta MP, Ammassari A, Melzi S, Zaccarelli M, Ladisa N, Sighinolfi L et al (2002) Treatment-related factors and highly active antiretroviral therapy adherence. J Acquir Immune Defic Syndr 31(Suppl 3):S128–S131CrossRefPubMedGoogle Scholar
  14. 14.
    Palleria C, Di Paolo A, Giofre C, Caglioti C, Leuzzi G, Sinischalchi A et al (2013) Pharmacokinetic drug-drug interaction and their implication in clinical management. J Res Med Sci 18(7):601–610PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  1. 1.College of PharmacyQatar UniversityDohaQatar
  2. 2.Faculty of Pharmaceutical SciencesThe University of British ColumbiaVancouverCanada

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