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Heterogeneity in Severe Asthma

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Severe Asthma

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Abstract

Although severe asthma, as defined in American Thoracic Society/European Respiratory Society guideline, represents only a small group of asthmatics, clearly it contributes to a significant portion of health cost and patient morbidity. This subcategory separation is considered the cornerstone of delivering precision care to individual severe asthma patient.

Instead of differentiating the definition between phenotypes and endotypes, we preferred to use a broad term “heterogeneity” to label this chapter. First, it is often difficult to break down between phenotypes and endotypes as clinical disease characteristics mostly link to distinct pathobiological mechanisms. Second, it is arbitrary and controversial to adopt some specific diseases into asthma phenotypes/endotypes (e.g., allergic bronchopulmonary aspergillosis) while excluding others. In this chapter, various facets associated with severe asthma will be discussed in detail whether or not they are determined as part of “severe asthma.”

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  1. Division of Allergy-Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA

    Chen Hsing Lin, Sultan Alandijani & Seong H. Cho

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  2. Department of Internal Medicine, Chonbuk National Univ. Medical School, Jeonju, Jollabuk-do, Korea (Republic of)

    So Ri Kim

  3. Department of Internal Medicine, Morsani College of Medicine, Tampa, Florida, USA

    Seong Ho Cho

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Lin, C.H., Alandijani, S., Cho, S.H. (2018). Heterogeneity in Severe Asthma. In: Lee, Y., Kim, S., Cho, S. (eds) Severe Asthma. Springer, Singapore. https://doi.org/10.1007/978-981-10-1998-2_2

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