Skip to main content

Fetal Cardiac Disease

  • Chapter
  • First Online:
  • 482 Accesses

Abstract

The optimal management of pregnancies involving fetal congenital anomalies is important because the events of perinatal period are strongly associated with perioperative mortality and long-term outcomes. Congenital heart disease (CHD) is one of the most prominent birth defects; however, few reports on obstetrical issues in pregnancy with fetal CHD have been published. In this chapter, we review antenatal and intrapartum management for fetuses with CHD focusing particularly on intrapartum electrical fetal heart rate (FHR) monitoring in CHD patients.

FHR monitoring has been widely used for antenatal and intrapartum management. Our previous study demonstrated that fetuses with structural heart anomalies tended to show variant heart rate patterns such as severe variable deceleration, recurrent late deceleration, prolonged deceleration, and loss of baseline variability. Single ventricle, isomerism, and tetralogy of Fallot frequently showed variant FHR patterns. Conversely, umbilical artery pH results showed that most CHD fetuses with variant FHR patterns did not have accompanying acidosis, even in cases of emergency Caesarean section (C-section). These data suggested that special consideration is needed when translating the findings of aberrant FHR patterns in fetuses with CHD. Although FHR monitoring is among the most validated tools to detect nonreassuring fetal status, additional strategies should be discussed in the future due to the difficulty of monitoring fetal well-being in CHD patients.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Holland BJ, Myers JA, Woods CR Jr (2015) Prenatal diagnosis of critical congenital heart disease reduces risk of death from cardiovascular compromise prior to planned neonatal cardiac surgery: a meta-analysis. Ultrasound Obstet Gynecol 45(6):631–638

    Article  CAS  Google Scholar 

  2. Levey A, Glickstein JS, Kleinman CS et al (2010) The impact of prenatal diagnosis of complex congenital heart disease on neonatal outcomes. Pediatr Cardiol 31:587–597

    Article  Google Scholar 

  3. Satomi G, Yasukouchi S, Shimizu T et al (1999) Has fetal echocardiography improved the prognosis of congenital heart disease? Comparison of patients with hypoplastic left heart syndrome with and without prenatal diagnosis. Pediatr Int 41:726–732

    Article  Google Scholar 

  4. Tworetzky W, McElhinney DB, Reddy VM et al (2001) Improved surgical outcome after fetal diagnosis of hypoplastic left heart syndrome. Circulation 103:1269–1273

    Article  CAS  Google Scholar 

  5. Coltri A, Burtera G et al (1999) Detection of transposition of the great arteries in fetuses reduces neonatal morbidity and mortality. Circulation 99:916–918

    Article  Google Scholar 

  6. Maeno YV, Kamenir SA, Sinclare B et al (1999) Prenatal features of ductus arteriosus constriction and restrictive foramen ovale in d-transposition of the great arteries. Circulation 99:1209–1214

    Article  CAS  Google Scholar 

  7. Duke C, Sharland GK, Jones AM et al (2001) Echocardiographic features and outcome of truncus arteriosus diagnosed during fetal life. Am J Cardiol 88:1379–1384

    Article  CAS  Google Scholar 

  8. Franklin O, Burch M, Manning N et al (2002) Prenatal diagnosis of coarctation of the aorta improves survival and reduces morbidity. Heart 87:67–69

    Article  CAS  Google Scholar 

  9. Pepas LP, Savis A, Jones A et al (2003) An echocardiographic study of tetralogy of Fallot in the fetus and infant. Heart 13:240–247

    Google Scholar 

  10. Smythe JF, Copel JA, Kleinman CS et al (1992) Outcome of prenatally detected cardiac malformation. Am J Cardiol 69:1471–1474

    Article  CAS  Google Scholar 

  11. Sholler GF, Kasparian NA, Pye VE et al (2011) Fetal and post-natal diagnosis of major congenital heart disease: implications for medical and psychological care in the current era. J Paediatr Child Health 47(10):717–722

    Article  Google Scholar 

  12. Crispi F, Gratacos E (2012) Fetal cardiac function: technical considerations and potential research and clinical applications. Fetal Diagn Ther 32:47–64

    Article  Google Scholar 

  13. Luterek K1, Szymusik I, Bartkowiak R et al (2011) N-terminal pro-B-type natriuretic peptide: a potential marker of fetal heart failure in hemolytic disease. Neuro Endocrinol Lett 32(5):657–662

    CAS  PubMed  Google Scholar 

  14. Wallenstein MB, Harper LM, Odibo AO et al (2012) Fetal congenital heart disease and intrauterine growth restriction: a retrospective cohort study. J Matern Fetal Neonatal Med 25(6):662–665

    Article  Google Scholar 

  15. Cedergrena MI, Källénb BA (2006) Obstetric outcome of 6346 pregnancies with infants affected by congenital heart defects. Eur J Obstet Gynecol Reprod Biol 125(2):211–216

    Article  Google Scholar 

  16. Gartie TJ, Linzey M, Freeman RK et al (1979) Fetal heart rate and fetal distress in fetuses with congenital anomalies. Obstet Gynecol 53:716–720

    Google Scholar 

  17. Biale Y, Brawer-Ostrovsky Y, Insler V (1985) Fetal heart rate tracing in fetuses with congenital malformation. J Reprod Med 30:43–47

    CAS  PubMed  Google Scholar 

  18. Terao T, Kawasahima Y, Noto H et al (1984) Neurological control of fetal heart rate in 20 cases of anencephalic fetuses. Am J Obstet Gynecol 149:201–208

    Article  CAS  Google Scholar 

  19. Ueda K, Ikeda T, Iwanaga N et al (2009) Intrapartum fetal heart rate monitoring in cases of congenital heart disease. Am J Obstet Gynecol 201(1):64.e1–64.e6

    Article  Google Scholar 

  20. National Institutes of Child Health and Human Development Research Planning Workshop (1997) Electronic fetal heart rate monitoring: research guideline for interpretation. Am J Obstet Gynecol 177:1385–1390

    Article  Google Scholar 

  21. Walsh CA et al (2014) Mode of delivery in pregnancies complicated by major fetal congenital heart disease: a retrospective cohort study. J Perinatol 34(12):901–905

    Article  CAS  Google Scholar 

  22. Gay E, Bornallet G, Gaucherand P et al (2015) Intrapartum electrocardiogram alteration in fetuses with congenital heart disease: a case-control study. Eur J Obstet Gynecol Reprod Biol 194(8):111–114

    Article  Google Scholar 

  23. Siddiqui S, Wilpers A, Myers M et al (2015) Autonomic regulation in fetuses with congenital heart disease. Early Hum Dev 91(3):195–198

    Article  Google Scholar 

  24. East CE, Begg L, Colditz PB et al (2014) Fetal pulse oximetry for fetal assessment in labour. Cochrane Database Syst Rev 7(10)

    Google Scholar 

  25. Pavlovic M, Acharya G, Huhta JC (2008) Controversies of fetal cardiac intervention. Early Hum Dev 84(3):149–153

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Keiko Ueda .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Science+Business Media Singapore

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Ueda, K. (2019). Fetal Cardiac Disease. In: Ikeda, T., Aoki-Kamiya, C. (eds) Maternal and Fetal Cardiovascular Disease. Springer, Singapore. https://doi.org/10.1007/978-981-10-1993-7_17

Download citation

  • DOI: https://doi.org/10.1007/978-981-10-1993-7_17

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-1991-3

  • Online ISBN: 978-981-10-1993-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics