Skip to main content
SpringerLink
Log in

Hypertrophic Cardiomyopathy

  • Chapter
  • First Online:
Maternal and Fetal Cardiovascular Disease

  • 466 Accesses

Abstract

In many cases with stable hypertrophic cardiomyopathy (HCM), the prognosis for pregnancy is comparatively favorable. However, heart failure, defined as New York Heart Association (NYHA) class III–IV, left ventricular ejection fraction <35–40%, and left ventricular outflow tract obstruction with mean pressure gradient >40–50 mmHg, requires strict caution during pregnancy or advice on avoidance of pregnancy. In pregnancy in these cases, caution should be exercised when circulating blood volume reaches its peak at around 30 gestational weeks, due to the high frequency of symptoms, especially increases in arrhythmia and pulmonary congestion.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Richardson P, McKenna W, Bristow M et al (1996) Report of the 1995 World Health Organization/International Society and Federation of Cardiology task force on the definition and classification of cardiomyopathies. Circulation 93:841842

    Google Scholar 

  2. JCS Joint Working Group (2016) Guidelines for diagnosis and treatment of patients with hypertrophic cardiomyopathy (JCS 2012). Circ J 80:753–774

    Article  Google Scholar 

  3. JCS Joint Working Group (2012) Guidelines for indication and management of pregnancy and delivery in women with heart disease (JCS 2010): digest version. Circ J 76:240–260

    Article  Google Scholar 

  4. Kodama K, Hamada M, Kazatani Y et al (1998) Clinical characteristics in Japanese patients with coexistent hypertrophic cardiomyopathy and coronary vasospasm. Angiology 49:849–855

    Article  CAS  Google Scholar 

  5. Ogimoto A, Shigematsu Y, Nakura J et al (2005) Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) in patients with coexistent hypertrophic cardiomyopathy and coronary spastic angina. J Mol Med 83:619–625

    Article  CAS  Google Scholar 

  6. Mukai M, Hamada M, Sumimoto T et al (1988) Disparate difference in preload reserve between myocardial hypertrophy due to essential hypertension and hypertrophic cardiomyopathy. J Hypertens Suppl 6(suppl 4):s138–s140

    Article  CAS  Google Scholar 

  7. Shigematsu Y, Hamada M, Suzuki M et al (1995) Mechanism of atrial fibrillation and increased incidence of thromboembolism in patients with hypertrophic cardiomyopathy. Jpn Circ J 59:329–336

    Article  CAS  Google Scholar 

  8. Maron BJ, McKenna WJ, Danielson GK et al (2003) American College of Cardiology/European Society of Cardiology clinical expert consensus document on hypertrophic cardiomyopathy. A report of the American College of Cardiology foundation task force on clinical expert consensus documents and the European Society of Cardiology committee for practice guidelines. J Am Coll Cardiol 42:1687–1713

    Article  Google Scholar 

  9. Christiaans I, van Engelen K, van Langen IM et al (2010) Risk stratification for sudden cardiac death in hypertrophic cardiomyopathy: systematic review of clinical risk markers. Europace 12:313–321

    Article  Google Scholar 

  10. Maron BJ (2010) Contemporary insights and strategies for risk stratification and prevention of sudden death in hypertrophic cardiomyopathy. Circulation 121:445–456

    Article  Google Scholar 

  11. Kubo T, Kitaoka H, Okawa M et al (2010) Hypertrophic cardiomyopathy in the elderly. Geriatr Gerontol Int 10:9–16

    Article  Google Scholar 

  12. Oakley GD, McGarry K, Limb DG, Oakley CM (1979) Management of pregnancy in patients with hypertrophic cardiomyopathy. Br Med J 1:1749–1750

    Article  CAS  Google Scholar 

  13. Siu SC, Sermer M, Colman JM, Alvarez AN, Mercier LA, Morton BC, Kells CM, Bergin ML, Kiess MC, Marcotte F, Taylor DA, Gordon EP, Spears JC, Tam JW, Amankwah KS, Smallhorn JF, Farine D, Sorensen S (2001) Prospective multicenter study of pregnancy outcomes in women with heart disease. Circulation 104:515–521

    Article  CAS  Google Scholar 

  14. Autore C, Conte MR, Piccininno M, Bernabo P, Bonfiglio G, Bruzzi P, Spirito P (2002) Risk associated with pregnancy in hypertrophic cardiomyopathy. J Am Coll Cardiol 40:1864–1869

    Article  Google Scholar 

  15. Avila WS, Rossi EG, Ramires JA, Grinberg M, Bortolotto MR, Zugaib M, da Luz PL (2003) Pregnancy in patients with heart disease: experience with 1,000 cases. Clin Cardiol 26:135–142

    Article  Google Scholar 

  16. Thaman R, Varnava A, Hamid MS, Firoozi S, Sachdev B, Condon M, Gimeno JR, Murphy R, Elliott PM, McKenna WJ (2003) Pregnancy related complications in women with hypertrophic cardiomyopathy. Heart 89:752–756

    Article  CAS  Google Scholar 

  17. Tanaka H, Kamiya C, Katsuragi S, Tanaka K, Miyoshi T, Tsuritani M, Yoshida M, Iwanaga N, Neki R, Yoshimatsu J, Ikeda T (2014) Cardiovascular events in pregnancy with hypertrophic cardiomyopathy. Circ J 78:2501–2506

    Article  Google Scholar 

  18. McKenna WJ, Deanfield J, Faruqui A et al (1981) Prognosis in hypertrophic cardiomyopathy: role of age and clinical, electrocardiographic and hemodynamic features. Am J Cardiol 47:532–538

    Article  CAS  Google Scholar 

  19. Nienaber CA, Hiller S, Spielmann RP et al (1990) Syncope in hypertrophic cardiomyopathy: multivariate analysis of prognostic determinants. J Am Coll Cardiol 15:948955

    Article  Google Scholar 

  20. Maron BJ, Roberts WC, Epstein SE et al (1982) Sudden death in hypertrophic cardiomyopathy: a profile of 78 patients. Circulation 65:1388–1394

    Article  CAS  Google Scholar 

  21. Geisterfer-Lowrence AAT, Kass S, Tanigawa G et al (1990) A molecular basis for familial hypertrophic cardiomyopathy: a β cardiac myosin heavy chain gene missense mutation. Cell 62:999–1006

    Article  Google Scholar 

  22. Kimura A (2010) Molecular basis of hereditary cardiomyopathy: abnormalities in calcium sensitivity, stretch response, stress response and beyond. J Hum Genet 55:81–90

    Article  CAS  Google Scholar 

  23. Landstrom AP, Ackerman MJ (2010) Mutation type is not clinically useful in predicting prognosis in hypertrophic cardiomyopathy. Circulation 122:2441–2450

    Article  Google Scholar 

  24. Watkins H, Ashrafian H, Redwood C (2011) Inherited cardiomyopathy. N Engl J Med 364(17):364–356

    Article  Google Scholar 

  25. Watkins H, McKenna WJ, Thierfelder L et al (1995) Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy. N Engl J Med 332:1058–1064

    Article  CAS  Google Scholar 

  26. Anan R, Greve G, Thierfelder L et al (1994) Prognostic implications of novel beta cardiac myosin heavy chain gene mutations that cause familial hypertrophic cardiomyopathy. J Clin Invest 93:280–285

    Article  CAS  Google Scholar 

  27. Ommen SR, Gersh BJ (2009) Sudden cardiac death risk in hypertrophic cardiomyopathy. Eur Heart J 30:25582559

    Article  Google Scholar 

  28. Christiaans I, Birnie E, van Langen IM et al (2010) The yield of risk stratification for sudden cardiac death in hypertrophic cardiomyopathy myosin-binding protein C gene mutation carriers: focus on predictive screening. Eur Heart J 31:842–848

    Article  CAS  Google Scholar 

  29. Ho CY (2010) Genetics and clinical destiny: improving care in hypertrophic cardiomyopathy. Circulation 122:24302440

    Article  Google Scholar 

  30. Force T, Bonow RO, Houser SR et al (2010) Research priorities in hypertrophic cardiomyopathy. Report of a working group of the National Heart, Lung, and Blood Institute. Circulation 122:1130–1133

    Article  Google Scholar 

  31. Turner GM, Oakley CM, Dixon HG (1968) Management of pregnancy complicated by hypertrophic obstructive cardiomyopathy. Br Med J 4:281–284

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Mie University School of Medicine, Tsu, Mie, Japan

    Hiroaki Tanaka

Authors
  1. Hiroaki Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hiroaki Tanaka .

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Mie, Japan

    Tomoaki Ikeda

  2. Department of Perinatology and Gynecology, National Cerebral and Cardiovascul Center, Suita, Osaka, Japan

    Chizuko Aoki-Kamiya

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Science+Business Media Singapore

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Tanaka, H. (2019). Hypertrophic Cardiomyopathy. In: Ikeda, T., Aoki-Kamiya, C. (eds) Maternal and Fetal Cardiovascular Disease. Springer, Singapore. https://doi.org/10.1007/978-981-10-1993-7_10

Download citation

  • DOI: https://doi.org/10.1007/978-981-10-1993-7_10

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-1991-3

  • Online ISBN: 978-981-10-1993-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation