Abstract
Ascorbic acid, dopamine and uric acid biomolecules are of utmost importance nowadays because of their significant relevance in maintaining physiological homeostasis. The interfering nature of ascorbic acid and very low concentration of dopamine (0.01–1 μM) in extracellular fluid pose a severe obstacle for sensitive and selective determination of these biomolecules. Electrochemical determination seems to be the most efficient choice for individual as well as determining these biomolecules together. To achieve high sensitivity and selectivity towards determination of these biomolecules we have explored the use of mesoporous nitrogen rich carbonaceous material (MNC) as a sensitive probe in the present study. MNC material have been synthesized and explored for simultaneous determination of ascorbic acid (AA), dopamine (DA) and uric acid (UA). The electrocatalytic activity of these materials for the oxidation of analyte molecules was examined by means of various voltammetric techniques. MNC materials show a superior sensitivity towards the oxidation of AA, DA, and UA with a lowest detection limit of 10, 1 and 10 nM, respectively.
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Joshi, A., Tharamani, C.N. (2016). Highly Sensitive Determination of Ascorbic Acid, Dopamine and Uric Acid Using Mesoporous Nitrogen Containing Carbon. In: B. D., P., Gummadi, S., Vadlani, P. (eds) Biotechnology and Biochemical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-10-1920-3_20
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DOI: https://doi.org/10.1007/978-981-10-1920-3_20
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