Quantification of Spike-LFP Synchronization
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To uncover more details on rhythmic neuronal synchronization, an increasingly interesting method is to relate spiking activity of individual neurons and local filed potentials (LFPs) of neural ensembles. Spike field coherence (SFC) is widely used to measure the synchronization between spike trains and LFPs. However, it is not suited to analyze the relationship between bursty spike trains and LFPs, particularly in high frequency band. To address this issue, a method, referred to as weighted spike field coherence (WSFC), is introduced in this chapter, which uses multiple copies of the first spike in every burst to calculate the coherence. In the calculation, the number of copies is equal to the spike count per burst. Moreover, many experiments have compared the strength of the association between spikes and rhythms present in LFP recordings. Most existing measures are dependent upon the total number of spikes, which renders comparison of spike-LFP synchronization across experimental contexts difficult. We introduce a robust procedure for quantifying spike-LFP synchronization which performs reliably for limited samples of data. The measure is referred to as spike-triggered correlation matrix synchronization (SCMS), which takes LFP segments centered on each spike as multichannel signals and calculates the index of spike-LFP synchronization by constructing a correlation matrix.