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Lanthanide-Doped Upconversion Nanoprobes

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Phosphors, Up Conversion Nano Particles, Quantum Dots and Their Applications

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Abstract

Lanthanide-doped upconversion nanoparticles (UCNPs) have attracted considerable interest due to their superior physicochemical features, such as large anti-Stokes shifts, low autofluorescence background, low toxicity, and high penetration depth, which make them extremely suitable for use as alternatives to conventional downshifting luminescence bioprobes such as organic dyes and quantum dots for various biological applications. Fundamental understanding the photophysics of lanthanide-doped UCNPs is of vital importance for discovering novel optical properties and exploring their new applications. In this chapter, we focus on the most recent advances in the development of lanthanide-doped UCNPs as potential luminescent nanobioprobes by means of our customized lanthanide photophysics measurement platforms specially designed for upconversion luminescence, which covers from their fundamental photophysics to bioapplications, including electronic structures (energy levels and local site symmetry of emitters), excited-state dynamics, UC luminescence enhancement strategies, and their promising applications for biodetection and bioimaging. Some future prospects and efforts toward this rapidly growing field are also envisioned.

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Acknowledgments

This work is supported by the 973 program of MOST of China (No. 2014CB845605), Special Project of National Major Scientific Equipment Development of China (No. 2012YQ120060), the NSFC (Nos. 51402294, 21501180, 11204302, 21201163, 11304314, U1305244, and 21325104), the CAS/SAFEA International Partnership Program for Creative Research Teams, and the CAS Strategic Priority Research Program and Scientific Equipment Development Project (Nos. XDA09030307 and YZ201210), Natural Science Fundation of Fujian Province for Young Scientists and Key Project (Nos. 2016J05057, 2014J05070, 2013J05038 and 2013H0060), and Chunmiao Project of Haixi Institute of Chinese Academy of Sciences (Nos. CMZX-2014-003 and CMZX-2016-002) and Youth Innovation Promotion Association of CAS (Nos. 2014264 and 2016277).

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  1. Key Laboratory of Optoelectronic Materials Chemistry and Physics and State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, Fujian, China

    Datao Tu, Wei Zheng, Ping Huang & Xueyuan Chen

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  1. Datao Tu
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Correspondence to Xueyuan Chen .

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  1. Department of Chemistry, National Taiwan University Department of Chemistry, Taipei, Taiwan

    Ru-Shi Liu

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Tu, D., Zheng, W., Huang, P., Chen, X. (2016). Lanthanide-Doped Upconversion Nanoprobes. In: Liu, RS. (eds) Phosphors, Up Conversion Nano Particles, Quantum Dots and Their Applications. Springer, Singapore. https://doi.org/10.1007/978-981-10-1590-8_8

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