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The Long and Short Non-coding RNAs in Cancer Biology pp 49–67Cite as

The Working Modules of Long Noncoding RNAs in Cancer Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 927))

Abstract

It is clear that RNA is more than just a messenger between gene and protein. The mammalian genome is pervasively transcribed, giving rise to tens of thousands of noncoding transcripts, especially long noncoding RNAs (lncRNAs). Whether all of these large transcripts are functional remains to be elucidated, but it is evident that there are many lncRNAs that seem not to be the “noise” of the transcriptome. Recent studies have set out to decode the regulatory role and functional diversity of lncRNAs in human physiological and pathological processes, and accumulating evidence suggests that most of the functional lncRNAs achieve their biological functions by controlling gene expression. In this chapter, we will organize these studies to provide a detailed description of the involvement of lncRNAs in the major steps of gene expression that include epigenetic regulation, RNA transcription, posttranscriptional RNA processing, protein translation, and posttranslational protein modification and highlight the molecular mechanisms through which lncRNAs function, involving the interactions between lncRNAs and other biological macromolecules.

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  1. Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan, China

    Ling Li & Xu Song

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  1. Ling Li
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  2. Xu Song
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Correspondence to Xu Song .

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  1. Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China

    Erwei Song

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© 2016 Springer Science+Business Media Singapore

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Li, L., Song, X. (2016). The Working Modules of Long Noncoding RNAs in Cancer Cells. In: Song, E. (eds) The Long and Short Non-coding RNAs in Cancer Biology. Advances in Experimental Medicine and Biology, vol 927. Springer, Singapore. https://doi.org/10.1007/978-981-10-1498-7_2

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