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Mechanism of Functional Expression of the Molecular Machines pp 21–61Cite as

Molecular Machines

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Part of the book series: SpringerBriefs in Molecular Science ((BRIEFSMOLECULAR))

Abstract

The ATP hydrolysis cycle is utilized in such processes as the unidirectional movement of myosin along F-actin, assistance in protein folding performed by a chaperonin, transport of diverse substrates across the membrane by an ABC transporter, and rotation of the central subunit within F1-ATPase. On the other hand, the proton motive force is utilized in the functional rotation of the multidrug efflux transporter AcrB. In this chapter, we elucidate the mechanism of these ordering processes. We also argue how the processes are coupled with the ATP hydrolysis cycle or the proton motive force. Like in the self-assembly processes, the key factor is the entropic effect originating from the translational displacement of water molecules in the system.

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Authors and Affiliations

  1. Institute of Advanced Energy, Kyoto University, Kyoto, Japan

    Masahiro Kinoshita

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  1. Masahiro Kinoshita
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Correspondence to Masahiro Kinoshita .

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Kinoshita, M. (2016). Molecular Machines. In: Mechanism of Functional Expression of the Molecular Machines. SpringerBriefs in Molecular Science. Springer, Singapore. https://doi.org/10.1007/978-981-10-1486-4_3

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