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Clinical Trial of Autologous Cord Blood Cell Therapy for Neonatal Hypoxic Ischemic Encephalopathy (HIE)

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Cell Therapy for Perinatal Brain Injury

Abstract

Cell-based therapy is attracting attention not only for its regenerative property but also for its long therapeutic time window. A growing number of studies in animal models with brain injuries have shown that cell therapies are beneficial. Among the variety of cell types to be used for cell therapies, autologous umbilical cord blood cells (UCBCs) are the most feasible; UCB contains several types of stem cells, the collection of the UCB is totally noninvasive and no ethical issues are involved, and UCBCs have no tumorigenicity. More than 20 preclinical studies have examined the effects of human UCBCs in models of neonatal brain injury; the majority of the studies were conducted in a rodent model of hypoxia-ischemia. Systemic administration of mononuclear fraction of UCB is the most extensively explored, and most of the studies have shown beneficial effects. Intravenous infusion of autologous non-cryopreserved volume- and red blood cell-reduced UCB is the most feasible method for cell therapy, especially when used at the acute phase of acute onset diseases. Fewer than ten clinical studies, including ours, using UCB for newborns with acute brain injury have been reported or listed on open registration websites, and only a few of the studies have reported the results, proving safety and feasibility and implying efficacy. No randomized control studies have been reported with respect to cell therapies during the newborn period. Further preclinical studies to optimize the treatment protocol and clinical trials to prove efficacy are warranted.

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Author information

Authors and Affiliations

  1. Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

    Masahiro Tsuji M.D., Ph.D.

  2. Department of Pediatrics, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan

    Haruo Shintaku M.D., Ph.D.

Authors
  1. Masahiro Tsuji M.D., Ph.D.
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  2. Haruo Shintaku M.D., Ph.D.
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Corresponding author

Correspondence to Masahiro Tsuji M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Pediatrics, Osaka City University Graduate School of Medicine, Osaka, Japan

    Haruo Shintaku

  2. Department of Pediatrics, University of Tokyo, Tokyo, Japan

    Akira Oka

  3. Department of Pediatrics, Yodogawa Christian Hospital, Osaka, Japan

    Makoto Nabetani

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© 2018 Springer Nature Singapore Pte Ltd.

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Tsuji, M., Shintaku, H. (2018). Clinical Trial of Autologous Cord Blood Cell Therapy for Neonatal Hypoxic Ischemic Encephalopathy (HIE). In: Shintaku, H., Oka, A., Nabetani, M. (eds) Cell Therapy for Perinatal Brain Injury. Springer, Singapore. https://doi.org/10.1007/978-981-10-1412-3_1

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  • DOI: https://doi.org/10.1007/978-981-10-1412-3_1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-1411-6

  • Online ISBN: 978-981-10-1412-3

  • eBook Packages: MedicineMedicine (R0)

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