Abstract
More than 55 % of US hospitals have electronic health records (EHRs); frequently these contain computerized decision support (CDS) in the form of alerts. Alerts are a common form of CDS often implemented for medication ordering and decision support to improve patient care. EHRs implement rules supplied by third-party vendors to help guide the dosing process include weight-based dosing. Since many of these rules are conservative, they result in noisy alerting and are therefore overridden by users. Alert fatigue is commonly studied and reported by providers. EHR implementers customize these rules to reduce noise. Adverse drug events are a common occurrence, prevalent in both adult and pediatric populations. However, there are few automated ways to identify adverse drug events. Weight-based dosing guidance for medication orders has limited functionality if the patient’s body weight is entered incorrectly. Despite safeguards intended to prevent weight data-entry errors, erroneous weights exist in patients’ charts. These pose a safety threat to patients, especially inpatients, whose medication doses may be calculated from the last recorded weight. In this chapter we will give an overview of pediatric clinical decision support in EHRs, the different modes and forms of CDS, as well as diving into several related and specific areas of CDS – medication dosing alerts and the detection of weight data entry errors. We will review these common sources of error and frustration in the EHR, how errors can be identified, and changes implemented to mitigate the errors.
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References
AAP. American Academy of Pediatrics: task force on medical informatics. Special requirements for electronic medical record systems in pediatrics. Pediatrics. 2001;108(2):513–5.
Aronsky D, Chan KJ, Haug PJ. Evaluation of a computerized diagnostic decision support system for patients with pneumonia. J Am Med Inform Assoc. 2001;8(5):473–85.
Ash JS, Sittig DF, Campbell EM, Guappone KP, Dykstra RH. Some unintended consequences of clinical decision support systems. AMIA Annu Symp Proc. 2007:26–30.
Aspden P, Institute of Medicine (U.S.), and Committee on Identifying and Preventing Medication Errors. Preventing medication errors. Quality chasm series. Washington, DC: National Academies Press; 2007.
Ayvaz S, Horn J, Hassanzadeh O, Zhu Q, Stan J, Tatonetti NP, Vilar S, Brochhausen M, Samwald M, Rastegar-Mojarad M. Toward a complete dataset of drug–drug interaction information from publicly available sources. J Biomed Inform. 2015;55:206–17.
Bakken S, Cimino JJ, Hripcsak G. Promoting patient safety and enabling evidence-based practice through informatics. Med Care. 2004;42(2):II-49–56.
Ball MJ. Hospital information systems: perspectives on problems and prospects, 1979 and 2002. Int J Med Inf. 2003;69(2):83–9.
Barbour AM, Fossler MJ, Barrett J. Practical considerations for dose selection in pediatric patients to ensure target exposure requirements. AAPS J. 2014;16(4):749–55.
Bates DW, Cohen M, Leape LL, Overhage JM, Shabot MM, Sheridan T. Reducing the frequency of errors in medicine using information technology. J Am Med Inform Assoc. 2001;8(4):299–308.
Beacher DR, Chang SZ, Rosen JS, Lipkin GS, McCarville MM, Quadri-Sheriff M, Kwon S, Lane JC, Binns HJ, Ariza AJ. Recognition of elevated blood pressure in an outpatient pediatric tertiary care setting. J Pediatr. 2015;166(5):1233–9. e1231.
Beeler PE, Bates DW, Hug BL. Clinical decision support systems. Swiss Med Wkly. 2014;144:w14073.
Brady TM, Neu AM, Miller 3rd ER, Appel LJ, Siberry GK, Solomon BS. Real-time electronic medical record alerts increase high blood pressure recognition in children. Clin Pediatr (Phila). 2015;54(7):667–75.
Brender J, Nøhr C, McNair P. Research needs and priorities in health informatics. Int J Med Inf. 2000;58:257–89.
Carpenter JD, Gorman PN. Using medication list – problem list mismatches as markers of potential error. Proc Amia Symp. 2002:106–110.
Carroll AE. How health information technology is failing to achieve its full potential. JAMA Pediatr. 2015;169(3):201–2.
CDC. Growth Charts. 2012. Retrieved from http://www.cdc.gov/growthcharts/.
Charles D, King J, Patel V, Furukawa MF. Adoption of electronic health record systems among US non-federal acute care hospitals: 2008–2012: Office of the National Coordinator for Health Information Technology. 2013.
Chaudhry B, Wang J, Wu S, Maglione M, Mojica W, Roth E, Morton SC, Shekelle PG. Systematic review: impact of health information technology on quality, efficiency, and costs of medical care. Ann Intern Med. 2006;144(10):742–52.
DeLeo J, Pucino F, Calis K, Crawford K, Dorworth T, Gallelli J. Patient-interactive computer system for obtaining medication histories. Am J Health Syst Pharm. 1993;50(11):2348–52.
Dexheimer J, Kirkendall E, Kouril M, Mahdi M, Minich T, Spoonder S. Reduction of medicatio-related alerts through ED alert feedback at the point of care. Poster presented at the AAP 2015 national conference San Diego, CA. 2015.
Dexter PR, Perkins SM, Maharry KS, Jones K, McDonald CJ. Inpatient computer-based standing orders vs physician reminders to increase influenza and pneumococcal vaccination rates: a randomized trial. JAMA. 2004;292(19):2366–71.
Dufendach KR, Eichenberger JA, McPheeters ML, Temple MW, Bhatia HL, Alrifai MW, Potter SA, Weinberg ST, Johnson KB, Lehmann CU. AHRQ comparative effectiveness technical briefs. Core functionality in pediatric electronic health records. Rockville: Agency for Healthcare Research and Quality (US); 2015.
Friedman R, Frank A. Use of conditional rule structure to automate clinical decision support: a comparison of artificial intelligence and deterministic programming techniques. Comput Biomed Res. 1983;16(4):378–94.
Galanter W, Falck S, Burns M, Laragh M, Lambert BL. Indication-based prescribing prevents wrong-patient medication errors in computerized provider order entry (CPOE). J Am Med Inform Assoc. 2013;20(3):477–81.
Goske MJ. Image gently: child-sizing radiation dose for children. JAMA Pediatr. 2013;167(11):1083.
Hansen ML, Gunn PW, Kaelber DC. Underdiagnosis of hypertension in children and adolescents. JAMA. 2007;298(8):874–9.
Häyrinen K, Saranto K, Nykänen P. Definition, structure, content, use and impacts of electronic health records: a review of the research literature. Int J Med Inf. 2008;77(5):291–304.
Holford N, Heo YA, Anderson B. A pharmacokinetic standard for babies and adults. J Pharm Sci. 2013;102(9):2941–52.
ISO/TR. ISO/TR 20514:2005(en) health informatics— electronic health record— definition, scope and context. Geneva: ISO/TR; 2005.
Ivanovska V, Rademaker CM, van Dijk L, Mantel-Teeuwisse AK. Pediatric drug formulations: a review of challenges and progress. Pediatrics. 2014;134(2):361–72.
Johnson KB, Lee CK, Spooner SA, Davison CL, Helmke JS, Weinberg ST. Automated dose-rounding recommendations for pediatric medications. Pediatrics. 2011;128(2):e422–8.
Johnson KB, Lehmann CU, Council on Clinical Information Technology of the American Academy of, P. Electronic prescribing in pediatrics: toward safer and more effective medication management. Pediatrics. 2013;131(4):e1350–6.
Kaelber D, Pickett F. Simple table to identify children and adolescents needing further evaluation of blood pressure. Pediatrics. 2009;123(6):e972–4.
Kaushal R, Barker KN, Bates DW. How can information technology improve patient safety and reduce medication errors in children’s health care? Arch Pediatr Adolesc Med. 2001;155(9):1002–7.
Kaushal R, Shojania KG, Bates DW. Effects of computerized physician order entry and clinical decision support systems on medication safety: a systematic review. Arch Intern Med. 2003;163(12):1409–16.
Kaushal R, Jaggi T, Walsh K, Fortescue EB, Bates DW. Pediatric medication errors: what do we know? What gaps remain? Ambul Pediatr. 2004;4(1):73–81.
Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE. Developmental pharmacology – drug disposition, action, and therapy in infants and children. N Engl J Med. 2003;349(12):1157–67.
Kesselheim AS, Cresswell K, Phansalkar S, Bates DW, Sheikh A. Clinical decision support systems could be modified to reduce ‘alert fatigue’ while still minimizing the risk of litigation. Health Aff (Millwood). 2011;30(12):2310–7.
Kim GR, Lehmann CU. Pediatric aspects of inpatient health information technology systems. Pediatrics. 2008;122(6):e1287–96.
Kirkendall E, Kouril M, Minich T, Spooner S. Analysis of electronic medication orders with large overdoses: opportunities for mitigating dosing errors. Appl Clin Inform. 2014;5:25–45.
Kirkendall ES, Kouril M, Dexheimer JW, Courter JD, Hagedorn P, Szczesniak R, Li D, Damania R, Minich T, Spooner SA. Automated identification of antibiotic overdoses and adverse drug events via analysis of prescribing alerts and medication administration records [Submitted for publication]. 2016.
Koren G, Barzilay Z, Greenwald M. Tenfold errors in administration of drug doses: a neglected iatrogenic disease in pediatrics. Pediatrics. 1986;77(6):848–9.
Lehmann CU, Weinberg ST, Alexander GM, Beyer EL, Del Beccaro MA, Francis AB, Handler EG, Johnson TD, Kirkendall ES, Lighter DE. Pediatric aspects of inpatient health information technology systems. Pediatrics. 2015;135(3):e756–68.
Lexi-Comp. “Lexi-Comp”: Lexi-Comp OnlineTM, Lexi-Comp, Lexi-Drugs OnlineTM, and Ohio Hudson. 2011.
McDonald CJ. Protocol-based computer reminders, the quality of care and the non-perfectability of man. N Engl J Med. 1976;295(24):1351–5.
McKibbon KA, Lokker C, Handler SM, Dolovich LR, Holbrook AM, O’Reilly D, Tamblyn R, Hemens BJ, Basu R, Troyan S. The effectiveness of integrated health information technologies across the phases of medication management: a systematic review of randomized controlled trials. J Am Med Inform Assoc. 2012;19(1):22–30.
McPhillips H, Stille C, Smith D, Pearson J, Stull J, Hecht J, Andrade S, Miller M, Davis R. Methodological challenges in describing medication dosing errors in children. In: Henriksen K, Battles JB, Marks ES, Lewin DI, editors. Advances in patient safety : from research to implementation, Concepts and methodology, vol. 2. Rockville: Agency for Healthcare Research and Quality; 2005. p. 213–23.
Middleton B, Bloomrosen M, Dente MA, Hashmat B, Koppel R, Overhage JM, Payne TH, Rosenbloom ST, Weaver C, Zhang J. Enhancing patient safety and quality of care by improving the usability of electronic health record systems: recommendations from AMIA. J Am Med Inform Assoc. 2013;20(e1):e2–8.
Nakamura MM, Ferris TG, DesRoches CM, Jha AK. Electronic health record adoption by children’s hospitals in the United States. Arch Pediatr Adolesc Med. 2010;164(12):1145–51.
National High Blood Pressure Education Program Working Group on High Blood Pressure in, C. and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004;114(2 Suppl 4th Report):555–76.
Rieder M, Goldstein D, Zinman H, Koren G. Tenfold errors in drug dosage. CMAJ. 1988;139(1):12.
Schirm E, Tobi H. Risk factors for unlicensed and off-label drug use in children outside the hospital. Pediatrics. 2003;111(2):291–5.
Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL. New equations to estimate GFR in children with CKD. J Am Soc Nephrol. 2009;20(3):629–37.
Sittig DF, Wright A, Osheroff JA, Middleton B, Teich JM, Ash JS, Campbell E, Bates DW. Grand challenges in clinical decision support. J Biomed Inform. 2008;41:387–92.
Spooner SA. Special requirements of electronic health record systems in pediatrics. Pediatrics. 2007;119(3):631–7.
Spooner SA, Dexheimer JW, Kouril M, Courter J, Hagedorn P, Damania R, Mahdi CM, Minich T, Kirkendall ES. Weight data-entry errors affect weight-based ordering and can pose risk to pediatric patients. Paper presented at the American Academy of Pediatrics National conference and Exposition, Washington, DC; 2015.
Stultz JS, Nahata MC. Complexities of clinical decision support illustrated by pediatric dosing alerts. Ann Pharmacother. 2015;49(11):1261–4.
Stultz JS, Porter K, Nahata MC. Prescription order risk factors for pediatric dosing alerts. Int J Med Inform. 2015;84(2):134–40.
Van Der Sijs H, Aarts J, Vulto A, Berg M. Overriding of drug safety alerts in computerized physician order entry. J Am Med Inform Assoc. 2006;13(2):138–47.
Zandieh SO, Goldmann DA, Keohane CA, Yoon C, Bates DW, Kaushal R. Risk factors in preventable adverse drug events in pediatric outpatients. J Pediatr. 2008;152(2):225–31.
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Dexheimer, J.W. et al. (2016). Clinical Decision Support and Alerting Mechanisms. In: Hutton, J. (eds) Pediatric Biomedical Informatics. Translational Bioinformatics, vol 10. Springer, Singapore. https://doi.org/10.1007/978-981-10-1104-7_9
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DOI: https://doi.org/10.1007/978-981-10-1104-7_9
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