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Chinese Herbal Medicine-Derived Products for Prevention or Treatment of Diseases Affecting Quality of Life

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Medicinal Plants - Recent Advances in Research and Development

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Abstract

Chinese herbal medicine (CHM) has been used for several thousands of years to treat human illness, which makes CHM the best source to provide valuable and unique information for modern drug discovery and development. Development of CHM products as adjunct therapies to augment the efficacy and offset the toxicity of Western medicine is an excellent approach for rapid advancement into US FDA-approved new drugs. Developing CHM products as high-quality dietary supplements must particularly emphasize standardization through qualitative and quantitative quality controls on single herbs and multiple herbs of the prescription formulas by using the most advanced scientific technology, especially toxicity profile testing. A combination of advanced medicinal chemistry and natural products chemistry, coupled with cutting-edge life science technology, will play a very important role for converting CHM products, especially the pure single active principles, through modification and synthesis into clinical trial candidates very efficiently and effectively. This chapter presents ten case studies of promising new drug discovery resulting from CHM-derived products: compounds from Curcuma longa (Jiang Huang), Antrodia camphorata (Chang-ku), Apium graveolens (Han Qin), Momordica charantia (Ku Gua), Monascus purpureus (Hong Chi), Astragalus membranaceus (Huang Chi), Scutellaria decoction (Huang Chin Tang), Eucommia ulmoides (Tu Chung), Ligusticum wallichii (Chuan Chiung), and Lycium barbarum (Kou Chi Tzu).

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Abbreviations

Ach:

Acetylcholine

AIDS:

Acquired immunodeficiency syndrome

ANS:

1-anilino-8-naphthalene-sulfonate

ATP:

Adenosine triphosphate

BDFI:

Bioactivity-directed fractionation and isolation

CD:

Circular dichroism

CHM:

Chinese herbal medicine

COX:

Cyclooxygenase

CRF:

Cancer-related fatigue

DNA:

Deoxyribonucleic acid

EDHF:

Endothelium-derived hyperpolarizing factor

EGFR-TKI:

Epidermal growth factor receptor tyrosine kinase inhibitor

FDA:

Food and Drug Administration

FRET:

Förster-type fluorescence resonance energy transfer

FTIR:

Fourier transform infrared spectroscopy

GAP:

Good agriculture practice

GCP:

Good clinical practice

GI:

Gastrointestinal

GLP:

Good laboratory practice

GMP:

Good manufacturing practice

GRAS:

Generally recognized as safe

HBV:

Hepatitis B virus

HCV:

Hepatitis C virus

HIV:

Human immunodeficiency virus

HIV-1:

Human immunodeficiency virus type 1

HPLC:

High-pressure liquid chromatography

HPV:

Human papilloma virus

IC50 :

Half maximal inhibitory concentration

IL:

Interleukin

IND:

Investigational New Drug

iNOS:

Inducible nitric oxide synthase

IOIP:

Idiopathic orbital inflammatory pseudotumors

IV:

Intravenous

LBP:

Lycium barbarum polysaccharide

MALDI-TOF MS:

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

mcIRBP:

Momordica charantia insulin receptor (IR)-binding protein

MCP:

Monocyte chemoattractant protein

MOEA:

Ministry of Economic Affairs

NBP:

3-n-butylphthalide

NOS:

Nitric oxide synthase

RCT:

Randomized controlled trial

RMR:

Red mold rice

SFDA:

State Food and Drug Administration

TCM:

Traditional Chinese medicine

TNF:

Tumor necrosis factor

US:

United States

WHO:

World Health Organization

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Acknowledgments

The authors would like to acknowledge support from three NIH grants: CA017625 and CA177584 from the National Cancer Institute and AI033066 from the Institute of Allergy and Infectious Diseases awarded to K.-H. Lee. Support in part was also received from the Taiwan Ministry of Health and Welfare Clinical Trial Center of Excellence, Taiwan (MOHW103-TDU-B-212-113002).

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Authors and Affiliations

  1. Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599-7568, USA

    Kuo-Hsiung Lee, Susan L. Morris-Natschke, Yu Zhao & Katie Musgrove

  2. Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, Taiwan

    Kuo-Hsiung Lee

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  1. Kuo-Hsiung Lee
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  2. Susan L. Morris-Natschke
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  3. Yu Zhao
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  4. Katie Musgrove
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Correspondence to Kuo-Hsiung Lee .

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Editors and Affiliations

  1. Department of Applied Chemistry, Chaoyang University of Technology, Taichung, Taiwan

    Hsin-Sheng Tsay

  2. Agricultural Biotechnology Research Center, Taipei, Taiwan

    Lie-Fen Shyur

  3. Department of Applied Chemistry, Chaoyang University of Technology, Taichung, Taiwan

    Dinesh Chandra Agrawal

  4. School of Pharmacy and Chinese Herbal Medicine Research Center, China Medical University, Taichung, Taiwan

    Yang-Chang Wu

  5. College of Agriculture and Natural Resources, Department of Forestry, National Chung Hsing University, Taichung, Taiwan

    Sheng-Yang Wang

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Lee, KH., Morris-Natschke, S.L., Zhao, Y., Musgrove, K. (2016). Chinese Herbal Medicine-Derived Products for Prevention or Treatment of Diseases Affecting Quality of Life. In: Tsay, HS., Shyur, LF., Agrawal, D., Wu, YC., Wang, SY. (eds) Medicinal Plants - Recent Advances in Research and Development. Springer, Singapore. https://doi.org/10.1007/978-981-10-1085-9_1

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