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Telocytes pp 77–103Cite as

Telocytes: New Players in Gallstone Disease

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 913))

Abstract

Cholesterol gallstone disease is highly prevalent in Western countries, particularly in women and some specific ethnic groups. The mechanisms behind the formation of gallstones are not clearly understood, but gallbladder dysmotility seems to be a key factor that triggers the precipitation of cholesterol microcrystals from supersaturated lithogenic bile.

Given that newly described interstitial cells, telocytes, are present in the gallbladder and they are located in close vicinity of smooth muscle cell and neural fibers possibly interfering with gallbladder motility or contractility, authors are trying to summarize the current knowledge on the role of telocytes with respect to disturbed gallbladder function in gallstone disease.

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Acknowledgments

The authors acknowledge the involvement of many colleagues who have participated in our studies and contributed with helpful discussions.

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Authors and Affiliations

  1. First Department of General, Oncological and Gastrointestinal Surgery, Jagiellonian University Medical College, 40 Kopernika St., 31-501, Krakow, Poland

    Artur Pasternak MD, PhD & Andrzej Matyja

  2. Department of Anatomy, Jagiellonian University Medical College, 12 Kopernika St., 31-034, Krakow, Poland

    Artur Pasternak MD, PhD

  3. Department of Pathophysiology, Jagiellonian University Medical College, 18 Czysta St., 31-121, Krakow, Poland

    Krzysztof Gil

Authors
  1. Artur Pasternak MD, PhD
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  2. Krzysztof Gil
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  3. Andrzej Matyja
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Correspondence to Artur Pasternak MD, PhD .

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Editors and Affiliations

  1. Zhongshan Hospital, Fudan University Medical School, Shanghai, China

    Xiangdong Wang

  2. Department of Cellular and Molecular Med, Carol Davila Univ of Medicine&Pharmacy, Bucharest, Romania

    Dragos Cretoiu

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Pasternak, A., Gil, K., Matyja, A. (2016). Telocytes: New Players in Gallstone Disease. In: Wang, X., Cretoiu, D. (eds) Telocytes. Advances in Experimental Medicine and Biology, vol 913. Springer, Singapore. https://doi.org/10.1007/978-981-10-1061-3_5

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