Skip to main content
SpringerLink
Log in

Immunohistochemistry of Telocytes in the Uterus and Fallopian Tubes

  • Chapter
  • First Online:
Book cover Telocytes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 913))

Abstract

The seminal work of Popescu and colleagues first demonstrated the existence of a new cell type – the telocytes. We were among the first who reported the presence of such cells in the female genital tract and performed TEM examinations, as well as immunohistochemical staining in the attempt to find a specific marker. Telocytes from rat and from the human uterus and from human fallopian tube were extensively investigated initially by comparison with interstitial cells of Cajal. Progress in telocyte research led to the identification of different subtypes suggestive for a heterogeneous telocyte population which can even coexist in the same location. As a consequence, the functions of TCs are still elusive and can be considered a versatile phenomenon that depends on a variety of conditions, including signal reception and transmission of information via extracellular vesicles or by direct intercellular contact.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Popescu LM, Hinescu ME, Ionescu N, et al. Interstitial cells of Cajal in pancreas. J Cell Mol Med. 2005;9:169–90.

    Article  CAS  PubMed  Google Scholar 

  2. Ciontea SM, Radu E, Regalia T, et al. C-kit immunopositive interstitial cells (Cajal-type) in human myometrium. J Cell Mol Med. 2005;9:407–20.

    Article  PubMed  Google Scholar 

  3. Popescu LM, Ciontea SM, Cretoiu D, et al. Novel type of interstitial cell (Cajal-like) in human fallopian tube. J Cell Mol Med. 2005;9:479–523.

    Article  CAS  PubMed  Google Scholar 

  4. Cretoiu D, Ciontea SM, Popescu LM, et al. Interstitial Cajal-like cells (ICLC) as steroid hormone sensors in human myometrium: immunocytochemical approach. J Cell Mol Med. 2006;10:789–95.

    Article  CAS  PubMed  Google Scholar 

  5. Popescu LM, Vidulescu C, Curici A, et al. Imatinib inhibits spontaneous rhythmic contractions of human uterus and intestine. Eur J Pharmacol. 2006;546:177–81.

    Article  CAS  PubMed  Google Scholar 

  6. Hinescu ME, Gherghiceanu M, Mandache E, et al. Interstitial Cajal-like cells (ICLC) in atrial myocardium: ultrastructural and immunohistochemical characterization. J Cell Mol Med. 2006;10:243–57.

    Article  CAS  PubMed  Google Scholar 

  7. Popescu LM, Ciontea SM, Cretoiu D. Interstitial Cajal-like cells in human uterus and fallopian tube. Ann N Y Acad Sci. 2007;1101:139–65.

    Article  CAS  PubMed  Google Scholar 

  8. Gherghiceanu M, Popescu LM. Interstitial Cajal-like cells (ICLC) in human resting mammary gland stroma. Transmission electron microscope (TEM) identification. J Cell Mol Med. 2005;9:893–910.

    Article  PubMed  Google Scholar 

  9. Radu E, Regalia T, Ceafalan L, et al. Cajal-type cells from human mammary gland stroma: phenotype characteristics in cell culture. J Cell Mol Med. 2005;9:748–52.

    Article  CAS  PubMed  Google Scholar 

  10. Suciu L, Popescu LM, Gherghiceanu M. Human placenta: de visu demonstration of interstitial Cajal-like cells. J Cell Mol Med. 2007;11:590–7.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Popescu LM, Faussone-Pellegrini MS. TELOCYTES – a case of serendipity: the winding way from Interstitial Cells of Cajal (ICC), via Interstitial Cajal-Like Cells (ICLC) to TELOCYTES. J Cell Mol Med. 2010;14:729–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Popescu LM, Manole CG, Gherghiceanu M, et al. Telocytes in human epicardium. J Cell Mol Med. 2010;14:2085–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Gherghiceanu M, Popescu LM. Cardiomyocyte precursors and telocytes in epicardial stem cell niche: electron microscope images. J Cell Mol Med. 2010;14:871–7.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Kostin S, Popescu LM. A distinct type of cell in myocardium: interstitial Cajal-like cells (ICLCs). J Cell Mol Med. 2009;13:295–308.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Suciu L, Nicolescu MI, Popescu LM. Cardiac telocytes: serial dynamic images in cell culture. J Cell Mol Med. 2010;14:2687–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Bani D, Formigli L, Gherghiceanu M, Faussone-Pellegrini MS. Telocytes as supporting cells for myocardial tissue organization in developing and adult heart. J Cell Mol Med. 2010;14:2531–8.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Kostin S. Myocardial telocytes: a specific new cellular entity. J Cell Mol Med. 2010;14:1917–21.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Faussone-Pellegrini MS, Bani D. Relationships between telocytes and cardiomyocytes during pre- and post-natal life. J Cell Mol Med. 2010;14:1061–3.

    PubMed  PubMed Central  Google Scholar 

  19. Manole CG, Cismasiu V, Gherghiceanu M, Popescu LM. Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis. J Cell Mol Med. 2011;15:2284–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Rusu MC, Pop F, Hostiuc S, et al. Telocytes form networks in normal cardiac tissues. Histol Histopathol. 2012;27:807–16.

    CAS  PubMed  Google Scholar 

  21. Gherghiceanu M, Manole CG, Popescu LM. Telocytes in endocardium: electron microscope evidence. J Cell Mol Med. 2010;14:2330–4.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Gherghiceanu M, Hinescu ME, Andrei F, et al. Interstitial Cajal-like cells (ICLC) in myocardial sleeves of human pulmonary veins. J Cell Mol Med. 2008;12:1777–81.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Yang Y, Sun W, Wu SM, et al. Telocytes in human heart valves. J Cell Mol Med. 2014. doi:10.1111/jcmm.12285.

    Google Scholar 

  24. Zhou Q, Wei L, Zhong C, et al. Cardiac telocytes are double positive for CD34/PDGFR-alpha. J Cell Mol Med. 2015;19:2036–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Rusu MC, Nicolescu MI, Jianu AM, et al. Esophageal telocytes and hybrid morphologies. Cell Biol Int. 2012;36:1079–88.

    Article  PubMed  Google Scholar 

  26. Chen X, Zheng Y, Manole CG, et al. Telocytes in human oesophagus. J Cell Mol Med. 2013;17:1506–12.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Cantarero Carmona I, Luesma Bartolome MJ, Junquera Escribano C. Identification of telocytes in the lamina propria of rat duodenum: transmission electron microscopy. J Cell Mol Med. 2011;15:26–30.

    Article  CAS  PubMed  Google Scholar 

  28. Cretoiu D, Cretoiu SM, Simionescu AA, Popescu LM. Telocytes, a distinct type of cell among the stromal cells present in the lamina propria of jejunum. Histol Histopathol. 2012;27:1067–78.

    CAS  PubMed  Google Scholar 

  29. Yang P, Liu Y, Ahmed N, et al. Ultrastructural identification of telocytes in the muscularis of chicken ileum. Exp Ther Med. 2015;10:2325–30.

    PubMed  PubMed Central  Google Scholar 

  30. Manetti M, Rosa I, Messerini L, Ibba-Manneschi L. Telocytes are reduced during fibrotic remodelling of the colonic wall in ulcerative colitis. J Cell Mol Med. 2015;19:62–73.

    Article  PubMed  Google Scholar 

  31. Xiao J, Wang F, Liu Z, Yang C. Telocytes in liver: electron microscopic and immunofluorescent evidence. J Cell Mol Med. 2013;17:1537–42.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Fu S, Wang F, Cao Y, et al. Telocytes in human liver fibrosis. J Cell Mol Med. 2015;19:676–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Hinescu ME, Ardeleanu C, Gherghiceanu M, Popescu LM. Interstitial Cajal-like cells in human gallbladder. J Mol Histol. 2007;38:275–84.

    Article  PubMed  Google Scholar 

  34. Matyja A, Gil K, Pasternak A, et al. Telocytes: new insight into the pathogenesis of gallstone disease. J Cell Mol Med. 2013;17:734–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Nicolescu MI, Bucur A, Dinca O, et al. Telocytes in parotid glands. Anat Rec (Hoboken). 2012;295:378–85.

    Article  Google Scholar 

  36. Alunno A, Ibba-Manneschi L, Bistoni O, et al. Telocytes in minor salivary glands of primary Sjogren’s syndrome: association with the extent of inflammation and ectopic lymphoid neogenesis. J Cell Mol Med. 2015;19:1689–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Nicolescu MI, Popescu LM. Telocytes in the interstitium of human exocrine pancreas: ultrastructural evidence. Pancreas. 2012;41:949–56.

    Article  PubMed  Google Scholar 

  38. Bosco C, Diaz E, Gutierrez R, et al. Ganglionar nervous cells and telocytes in the pancreas of Octodon degus: extra and intrapancreatic ganglionar cells and telocytes in the degus. Auton Neurosci. 2013;177:224–30.

    Article  PubMed  Google Scholar 

  39. Padhi S, Sarangi R, Mallick S. Pancreatic extragastrointestinal stromal tumors, interstitial Cajal like cells, and telocytes. JOP. 2013;14:1–14.

    PubMed  Google Scholar 

  40. Zheng Y, Li H, Manole CG, et al. Telocytes in trachea and lungs. J Cell Mol Med. 2011;15:2262–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Rusu MC, Jianu AM, Mirancea N, et al. Tracheal telocytes. J Cell Mol Med. 2012;16:401–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Popescu LM, Gherghiceanu M, Suciu LC, et al. Telocytes and putative stem cells in the lungs: electron microscopy, electron tomography and laser scanning microscopy. Cell Tissue Res. 2011;345:391–403.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Qi G, Lin M, Xu M, et al. Telocytes in the human kidney cortex. J Cell Mol Med. 2012;16:3116–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Zheng Y, Zhu T, Lin M, et al. Telocytes in the urinary system. J Transl Med. 2012;10:188.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Gevaert T, De Vos R, Van Der Aa F, et al. Identification of telocytes in the upper lamina propria of the human urinary tract. J Cell Mol Med. 2012;16:2085–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Vannucchi MG, Traini C, Guasti D, et al. Telocytes subtypes in human urinary bladder. J Cell Mol Med. 2014. doi:10.1111/jcmm.12375.

    PubMed  PubMed Central  Google Scholar 

  47. Yang J, Chi C, Liu Z, et al. Ultrastructure damage of oviduct telocytes in rat model of acute salpingitis. J Cell Mol Med. 2015;19:1720–8.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Yang XJ, Yang J, Liu Z, et al. Telocytes damage in endometriosis-affected rat oviduct and potential impact on fertility. J Cell Mol Med. 2015;19:452–62.

    Article  CAS  PubMed  Google Scholar 

  49. Cretoiu SM, Simionescu AA, Caravia L, et al. Complex effects of imatinib on spontaneous and oxytocin-induced contractions in human non-pregnant myometrium. Acta Physiol Hung. 2011;98:329–38.

    Article  CAS  PubMed  Google Scholar 

  50. Hatta K, Huang ML, Weisel RD, Li RK. Culture of rat endometrial telocytes. J Cell Mol Med. 2012;16:1392–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Cretoiu SM, Cretoiu D, Marin A, et al. Telocytes: ultrastructural, immunohistochemical and electrophysiological characteristics in human myometrium. Reproduction. 2013;145:357–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Hutchings G, Williams O, Cretoiu D, Ciontea SM. Myometrial interstitial cells and the coordination of myometrial contractility. J Cell Mol Med. 2009;13:4268–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Ullah S, Yang P, Zhang L, et al. Identification and characterization of telocytes in the uterus of the oviduct in the Chinese soft-shelled turtle, Pelodiscus sinensis: TEM evidence. J Cell Mol Med. 2015;18:2385–92.

    Article  Google Scholar 

  54. Suciu L, Popescu LM, Gherghiceanu M, et al. Telocytes in human term placenta: morphology and phenotype. Cells Tissues Organs. 2010;192:325–39.

    Article  CAS  PubMed  Google Scholar 

  55. Bosco C, Diaz E, Gutierrez R, et al. Placental hypoxia developed during preeclampsia induces telocytes apoptosis in chorionic villi affecting the maternal-fetus metabolic exchange. Curr Stem Cell Res Ther. 2016;11:420–5.

    Google Scholar 

  56. Bosco C, Diaz E, Gutierrez R, et al. A putative role for telocytes in placental barrier impairment during preeclampsia. Med Hypotheses. 2015;84:72–7.

    Article  CAS  PubMed  Google Scholar 

  57. Popescu LM, Andrei F, Hinescu ME. Snapshots of mammary gland interstitial cells: methylene-blue vital staining and c-kit immunopositivity. J Cell Mol Med. 2005;9:476–7.

    Article  CAS  PubMed  Google Scholar 

  58. Mou Y, Wang Y, Li J, et al. Immunohistochemical characterization and functional identification of mammary gland telocytes in the self-assembly of reconstituted breast cancer tissue in vitro. J Cell Mol Med. 2013;17:65–75.

    Article  CAS  PubMed  Google Scholar 

  59. Cantarero I, Luesma MJ, Junquera C. The primary cilium of telocytes in the vasculature: electron microscope imaging. J Cell Mol Med. 2011;15:2594–600.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Li H, Lu S, Liu H, et al. Scanning electron microscope evidence of telocytes in vasculature. J Cell Mol Med. 2014;18:1486–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Zhang HQ, Lu SS, Xu T, et al. Morphological evidence of telocytes in mice aorta. Chin Med J (Engl). 2015;128:348–52.

    Article  Google Scholar 

  62. Briggs Boedtkjer D, Rumessen J, Baandrup U, et al. Identification of interstitial Cajal-like cells in the human thoracic duct. Cells Tissues Organs. 2013;197:145–58.

    Article  CAS  PubMed  Google Scholar 

  63. Hinescu ME, Popescu LM, Gherghiceanu M, Faussone-Pellegrini MS. Interstitial Cajal-like cells in rat mesentery: an ultrastructural and immunohistochemical approach. J Cell Mol Med. 2008;12:260–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Hinescu ME, Gherghiceanu M, Suciu L, Popescu LM. Telocytes in pleura: two- and three-dimensional imaging by transmission electron microscopy. Cell Tissue Res. 2011;343:389–97.

    Article  PubMed  Google Scholar 

  65. Popescu LM, Manole E, Serboiu CS, et al. Identification of telocytes in skeletal muscle interstitium: implication for muscle regeneration. J Cell Mol Med. 2011;15:1379–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Suciu LC, Popescu BO, Kostin S, Popescu LM. Platelet-derived growth factor receptor-beta-positive telocytes in skeletal muscle interstitium. J Cell Mol Med. 2012;16:701–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Diaz-Flores L, Gutierrez R, Saez FJ, et al. Telocytes in neuromuscular spindles. J Cell Mol Med. 2013;17:457–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Rusu MC, Mirancea N, Manoiu VS, et al. Skin telocytes. Ann Anat. 2012;194:359–67.

    Article  CAS  PubMed  Google Scholar 

  69. Cretoiu D, Gherghiceanu M, Hummel E, et al. FIB-SEM tomography of human skin telocytes and their extracellular vesicles. J Cell Mol Med. 2015;19:714–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Manole CG, Gherghiceanu M, Simionescu O. Telocyte dynamics in psoriasis. J Cell Mol Med. 2015;19:1504–19.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Kang Y, Zhu Z, Zheng Y, et al. Skin telocytes versus fibroblasts: two distinct dermal cell populations. J Cell Mol Med. 2015;19:2530–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Luesma MJ, Gherghiceanu M, Popescu LM. Telocytes and stem cells in limbus and uvea of mouse eye. J Cell Mol Med. 2013;17:1016–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Corradi LS, Jesus MM, Fochi RA, et al. Structural and ultrastructural evidence for telocytes in prostate stroma. J Cell Mol Med. 2013;17:398–406.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Li H, Zhang H, Yang L, et al. Telocytes in mice bone marrow: electron microscope evidence. J Cell Mol Med. 2014;18:975–8.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Popescu BO, Gherghiceanu M, Kostin S, et al. Telocytes in meninges and choroid plexus. Neurosci Lett. 2012;516:265–9.

    Article  CAS  PubMed  Google Scholar 

  76. Xu T, Lu S, Zhang H. Transmission electron microscope evidence of telocytes in canine dura mater. J Cell Mol Med. 2016. doi:10.1111/jcmm.12726.

    Google Scholar 

  77. Dawidowicz J, Szotek S, Matysiak N, et al. Electron microscopy of human fascia lata: focus on telocytes. J Cell Mol Med. 2015;19:2500–6.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Yang P, Ahmad N, Hunag Y, et al. Telocytes: novel interstitial cells present in the testis parenchyma of the Chinese soft-shelled turtle Pelodiscus sinensis. J Cell Mol Med. 2015;19:2888–99.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Chang Y, Li C, Gan L, et al. Telocytes in the spleen. PLoS One. 2015;10:e0138851.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  80. Cretoiu SM, Popescu LM. Telocytes revisited. Biomol Concepts. 2014;5:353–69.

    Article  CAS  PubMed  Google Scholar 

  81. Cretoiu SM, Cretoiu D, Popescu LM. Human myometrium – the ultrastructural 3D network of telocytes. J Cell Mol Med. 2012;16:2844–9.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Gherghiceanu M, Popescu LM. Cardiac telocytes – their junctions and functional implications. Cell Tissue Res. 2012;348:265–79.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Fertig ET, Gherghiceanu M, Popescu LM. Extracellular vesicles release by cardiac telocytes: electron microscopy and electron tomography. J Cell Mol Med. 2014;18:1938–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Cismasiu VB, Radu E, Popescu LM. miR-193 expression differentiates telocytes from other stromal cells. J Cell Mol Med. 2011;15:1071–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Zheng Y, Zhang M, Qian M, et al. Genetic comparison of mouse lung telocytes with mesenchymal stem cells and fibroblasts. J Cell Mol Med. 2013;17:567–77.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Cismasiu VB, Popescu LM. Telocytes transfer extracellular vesicles loaded with microRNAs to stem cells. J Cell Mol Med. 2015;19:351–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. Zheng Y, Cretoiu D, Yan G, et al. Protein profiling of human lung telocytes and microvascular endothelial cells using iTRAQ quantitative proteomics. J Cell Mol Med. 2014;18:1035–59.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Zheng Y, Cretoiu D, Yan G, et al. Comparative proteomic analysis of human lung telocytes with fibroblasts. J Cell Mol Med. 2014;18:568–89.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Albulescu R, Tanase C, Codrici E, et al. The secretome of myocardial telocytes modulates the activity of cardiac stem cells. J Cell Mol Med. 2015;19:1783–94.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. Chi C, Jiang XJ, Su L, et al. In vitro morphology, viability and cytokine secretion of uterine telocyte-activated mouse peritoneal macrophages. J Cell Mol Med. 2015. doi:10.1111/jcmm.12711.

    Google Scholar 

  91. Sun X, Zheng M, Zhang M, et al. Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes. J Cell Mol Med. 2014;18:801–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. Zheng M, Sun X, Zhang M, et al. Variations of chromosomes 2 and 3 gene expression profiles among pulmonary telocytes, pneumocytes, airway cells, mesenchymal stem cells and lymphocytes. J Cell Mol Med. 2014;18:2044–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Wang J, Ye L, Jin M, Wang X. Global analyses of Chromosome 17 and 18 genes of lung telocytes compared with mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells, and lymphocytes. Biol Direct. 2015;10:9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  94. Zhu Y, Zheng M, Song D, et al. Global comparison of chromosome X genes of pulmonary telocytes with mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells, and lymphocytes. J Transl Med. 2015;13:318.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  95. Song D, Cretoiu D, Zheng M, et al. Comparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types. J Cell Mol Med. 2016. doi:10.1111/jcmm.12746.

    Google Scholar 

  96. Salama N. Immunohistochemical characterization of telocytes in rat uterus in different reproductive states. Egypt J Histol. 2013;36:185–94.

    Article  Google Scholar 

  97. Rosenbaum ST, Svalo J, Nielsen K, et al. Immunolocalization and expression of small-conductance calcium-activated potassium channels in human myometrium. J Cell Mol Med. 2012;16:3001–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  98. Campeanu RA, Radu BM, Cretoiu SM, et al. Near-infrared low-level laser stimulation of telocytes from human myometrium. Lasers Med Sci. 2014;29:1867–74.

    Article  PubMed  PubMed Central  Google Scholar 

  99. Faussone-Pellegrini MS, Popescu LM. Telocytes. Biomol. Concepts. 2011;2:481–9.

    Google Scholar 

  100. Cretoiu SM, Radu B, Banciu A, et al. Isolated human uterine telocytes: immunocytochemistry and electrophysiology of T-type calcium channels. Histochem Cell Biol. 2014:1–12. doi:10.1007/s00418-014-1268-0.

    Google Scholar 

  101. Cretoiu SM, Cretoiu D, Suciu L, Popescu LM. Interstitial Cajal-like cells of human fallopian tube express estrogen and progesterone receptors. J Mol Histol. 2009;40:387–94.

    Article  CAS  PubMed  Google Scholar 

  102. Yang XJ, Wei W, Zhao J, Zheng FY. Inhibitory effects of methotrexate on spontaneous motility and Cajal-like type of tubal interstitial cells in rabbit oviduct. Fertil Steril. 2012;98:215–21.

    Article  CAS  PubMed  Google Scholar 

  103. Yang XJ, Xu JY, Shen ZJ, Zhao J. Immunohistochemical alterations of Cajal-like type of tubal interstitial cells in women with endometriosis and tubal ectopic pregnancy. Arch Gynecol Obstet. 2013;288:1295–300.

    Article  CAS  PubMed  Google Scholar 

  104. Horn LC, Meinel A, Hentschel B. c-kit/CD 117 positive cells in the myometrium of pregnant women and those with uterine endometriosis. Arch Gynecol Obstet. 2012;286:105–7.

    Article  CAS  PubMed  Google Scholar 

  105. Terada T. Gastrointestinal stromal tumor of the uterus: a case report with genetic analyses of c-kit and PDGFRA genes. Int J Gynecol Pathol. 2009;28:29–34.

    Article  PubMed  Google Scholar 

  106. Ardeleanu C, Bussolati G. Telocytes are the common cell of origin of both PEComas and GISTs: an evidence-supported hypothesis. J Cell Mol Med. 2011;15:2569–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  107. Roatesi I, Radu BM, Cretoiu D, Cretoiu SM. Uterine telocytes: a review of current knowledge. Biol Reprod. 2015;93:10.

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by the Romanian National Authority for Scientific Research CNCS-UEFISCDI project numbers 82/2012 and 194/2014.

Author information

Authors and Affiliations

  1. Victor Babeş National Institute of Pathology, Bucharest, 050096, Romania

    Sanda Maria Cretoiu

  2. Division of Cell Biology and Histology, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., Bucharest, 050474, Romania

    Sanda Maria Cretoiu

Authors
  1. Sanda Maria Cretoiu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sanda Maria Cretoiu .

Editor information

Editors and Affiliations

  1. Zhongshan Hospital, Fudan University Medical School, Shanghai, China

    Xiangdong Wang

  2. Department of Cellular and Molecular Med, Carol Davila Univ of Medicine&Pharmacy, Bucharest, Romania

    Dragos Cretoiu

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media Singapore

About this chapter

Cite this chapter

Cretoiu, S.M. (2016). Immunohistochemistry of Telocytes in the Uterus and Fallopian Tubes. In: Wang, X., Cretoiu, D. (eds) Telocytes. Advances in Experimental Medicine and Biology, vol 913. Springer, Singapore. https://doi.org/10.1007/978-981-10-1061-3_22

Download citation

Publish with us

Policies and ethics

Search

Navigation