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Telocytes pp 177–191Cite as

Telocyte Behaviour During Inflammation, Repair and Tumour Stroma Formation

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 913))

Abstract

In this chapter, we outline the role of human CD34+ stromal cells/telocytes (CD34+ SC/TCs) as progenitor cells during repair. The in vivo activation phenomena of CD34+ SC/TCs in this process include increased size; separation from the neighbouring structures (mainly of the vascular walls); association with inflammatory cells, predominantly macrophages; development of the organelles of synthesis (rough endoplasmic reticulum and Golgi apparatus); cell proliferation with presence of mitosis and high proliferative index (transit-amplifying cells); and fibroblastic and myofibroblastic differentiation. A procedure to study these tissue-resident cells, comparison of their behaviour in vivo and in vitro and different behaviour depending on location, time, type of injury (including tumour stroma) and greater or lesser proximity to the injury are also considered.

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Authors and Affiliations

  1. Department of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain

    L. Díaz-Flores, R. Gutiérrez, M. González-Gómez, L. Díaz-Flores Jr, F. Valladares & N. Rancel

  2. Department of Cell Biology and Histology, UFI11/44, School of Medicine and Dentistry, University of the Basque Country, UPV/EHU, Leioa, Spain

    F. J. Sáez

  3. Department of Cell Biology and Histology, School of Medicine, Regional Campus of International Excellence, “Campus Mare Nostrum” University of Murcia, Murcia, Spain

    J. F. Madrid

Authors
  1. L. Díaz-Flores
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  2. R. Gutiérrez
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  3. M. González-Gómez
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  4. L. Díaz-Flores Jr
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  5. F. Valladares
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  6. N. Rancel
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  7. F. J. Sáez
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Correspondence to L. Díaz-Flores .

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Editors and Affiliations

  1. Zhongshan Hospital, Fudan University Medical School, Shanghai, China

    Xiangdong Wang

  2. Department of Cellular and Molecular Med, Carol Davila Univ of Medicine&Pharmacy, Bucharest, Romania

    Dragos Cretoiu

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Díaz-Flores, L. et al. (2016). Telocyte Behaviour During Inflammation, Repair and Tumour Stroma Formation. In: Wang, X., Cretoiu, D. (eds) Telocytes. Advances in Experimental Medicine and Biology, vol 913. Springer, Singapore. https://doi.org/10.1007/978-981-10-1061-3_12

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