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Perspectives in Translational Research in Life Sciences and Biomedicine pp 233–262Cite as

Subchapter-C: Translational Outcome Research with Date Extracts as Functional Food in Diseases Involving Oxi-Flammatory Pathways.

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Abstract

Fruit of date palm (Phoenix sylvestris L.) is edible and used as an antigeriatric, antioxidant ethnomedicine. In this study, three different types of date extracts, namely methanolic, acidic ethanolic and basic ethanolic, were evaluated for their putative in vitro scavenging effects on reactive oxygen species (ROS) where scavenging of hydroxyl radicals (basic ethanolic > acidic ethanolic > methanolic), superoxide radicals (acidic ethanolic > basic ethanolic > methanolic), and DPPH radical (acidic ethanolic > methanolic > basic ethanolic), [nitric oxide (NO)] (methanolic > acidic ethanolic > basic ethanolic) and inhibition of lipid peroxidation (basic ethanolic > acidic ethanolic > methanolic) were found to occur in a dose-dependent manner. Their flavonoid and phenolic contents proved to be the source of this potent free radical scavenging activity and indicated a direct correlation with their total antioxidant capacity. On human embryonic kidney cell line (HEK) and murine RAW macrophages, bacterial lipopolysaccharide (LPS)-induced inflammation, the date extracts applied therapeutically inhibit intracellular oxidative stress significantly. This reinstatement of cellular homeostasis presumably occurs via mitochondrial pathways.

The work have been published as:

(1) Mukherjee, K., Paul, P., and Ray Banerjee, E. Free radical scavenging activities of date palm (Pheonix sylvestris) fruit extracts. (2014) Natural Products Chemistry & Research. 2:151. Doi:10.4172/2329-6836.1000151.

(2) Mukherjee, K., Paul, P., and Ray Banerjee, E. Evaluation of date palm (Phoenix sylvestris) fruit extracts as functional food. (2014) International Journal of Science, Engineering and Technology. 3(11): 1-8. ISSN: 2277-1581.

(3) Das, R., Paul, P., Mukherjee, K., Mitra, S., Singh, U.P., and Ray Banerjee, E. Anti-Oxiflammatory profile of date extracts (Phoenix sylvestris). (2015) Biomedical Research and Therapy. 2(5): 15-38. DOI: http://dx.doi.org/10.15419/bmrat.v2i5.79, (ISSN: 2198-4093).

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  1. Department of Zoology, University of Calcutta, Kolkata, India

    Ena Ray Banerjee

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Ray Banerjee, E. (2016). Subchapter-C: Translational Outcome Research with Date Extracts as Functional Food in Diseases Involving Oxi-Flammatory Pathways.. In: Perspectives in Translational Research in Life Sciences and Biomedicine. Springer, Singapore. https://doi.org/10.1007/978-981-10-0989-1_15

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