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Drug Targeting and Delivery

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Basic and Applied Aspects of Biotechnology

Abstract

Drug delivery is defined as mechanisms to introduce pharmaceutical compounds to human in order to achieve therapeutic effects. We have come a long way since chewing medicinal plants and inhaling soot from medicinal substance were the only form of drug delivery. These approaches lacked consistency and uniformity of drug delivery. Since then there has been a continuous effort to discover and improve drug delivery routes and drug delivery systems. Conventional drug delivery system includes drug delivery via oral route as solutions, suspensions, emulsions, and tablets. Some are delivered systemically via injections and intravenous application. Medications are applied topically as lotions and gels. Nasal route is used for drug delivery to lungs by inhalers and nebulizers. Apart from antibiotics, vaccines, and chemical compounds, modern medicine includes recombinant DNA, insulin, interferon, interleukin, erythropoietin, tissue plasminogen activator, and other peptides and macromolecules as drugs that require efficient drug delivery systems. Traditional drug delivery systems suffer from various limitations such as low bioavailability, intolerance, toxic side effects, reduced plasma half-life, higher concentration, and low efficacy. The hydrophilic drugs have difficulty in passing through the cell membrane. Systemically delivered drugs reach all the organs irrespective of the affected organ. This causes toxic side effects on the healthy cells. The drugs tend to degrade fast in the plasma so higher doses of drug are required and hence it becomes toxic with reduced efficacy and are expensive. The biological barriers exclude the drug from reaching the affected cells and tissues. Efficient drug targeting can improve drug delivery efficacy, reduce side effects, and lower treatment cost. Hence, much effort is given on the development of novel carriers that would meet the requirement of drug delivery systems. The main areas of research are to increase bioavailability of the drugs, increase plasma half-life, and target to specific organs or cells. This would result in lowering the dose, which would also lower drug-induced toxicity, protect bystander cells and organs from adverse side effects, and reduce medical expenses. In this chapter, we will discuss the biological barriers, advances in drug delivery systems, drug targeting, and their application in diseases.

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References

  1. Allen TM, Cullis PR (2004) Drug delivery systems: entering the mainstream. Science 303:1818–1822

    Article  CAS  Google Scholar 

  2. Batrakova E, Gendelman HE, Kabanov AV (2011) Cell-mediated drugs delivery. Expert Opin Drug Deliv 8:415–433

    Article  CAS  Google Scholar 

  3. Bechara C, Sagan S (2013) Cell-penetrating peptides: 20 years later, where do we stand? FEBS Lett 587:1693–1702

    Article  CAS  Google Scholar 

  4. Bhattarai N, Gunn J, Zhang M (2010) Chitosan-based hydrogels for controlled, localized drug delivery. Adv Drug Deliv Rev 62:83–99

    Article  CAS  Google Scholar 

  5. Bhowmik A, Khan R, Ghosh MK (2015) Blood brain barrier: a challenge for effectual therapy of brain tumors. BioMed Res Int. doi:10.1155/2015/320941

    Google Scholar 

  6. Cai J, Ma H, Huang F et al (2013) Correlation of bevacizumab-induced hypertension and outcomes of metastatic colorectal cancer patients treated with bevacizumab: a systematic review and meta-analysis. World J Surg Oncol 11:306

    Article  Google Scholar 

  7. Cancer multidrug resistance (2000) Nature biotechnology vol 18 Supplement (Reprinted from Nat. Biotechnol (1999)17:94–95)

    Google Scholar 

  8. Cone RA (2009) Barrier properties of mucus. Adv Drug Deliv Rev 61:75–85

    Article  CAS  Google Scholar 

  9. Elias PM (2008) Skin barrier function. Curr Allergy Asthma Rep 8(4):299–305

    Article  CAS  Google Scholar 

  10. Encyclopedia of Medical Devices and Instrumentation (2006) Second edition. In Webster JG (ed) Copyright Wiley, India

    Google Scholar 

  11. Fay F, Scott C (2011) Antibody-targeted nanoparticles for cancer therapy. Immunotherapy 3:381–384

    Article  CAS  Google Scholar 

  12. Feingold KR, Elias PM (2014) Role of lipids in the formation and maintenance of the cutaneous permeability barrier. Biochim Biophys Acta 1841:280–294

    Article  CAS  Google Scholar 

  13. Flaherty KT, Infante JR, Daud A et al (2012) Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 367:1694–1703

    Article  CAS  Google Scholar 

  14. Gao Y et al (2014) Nanotechnology-based intelligent drug design for cancer metastasis treatment. Biotechnol Adv 32:761–777

    Article  CAS  Google Scholar 

  15. Gore L, DeGregori J, Porter CC (2013) Targeting developmental pathways in children with cancer: what price success? Lancet Oncol 4:e70–e78

    Article  Google Scholar 

  16. Guterres SS, Alves MP, Pohlmann AR (2007) Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications. Drug Target Insights 2:147–157

    Google Scholar 

  17. Higgins CF (2007) Multiple molecular mechanisms for multidrug resistance transporters. Nature 446:749–757

    Article  CAS  Google Scholar 

  18. Jayasena SD (1999) Aptamers: an emerging class of molecules that rival antibodies in diagnostics. Clin Chem 45:1628–1650

    CAS  Google Scholar 

  19. Keefe AD, Pai S, Ellington A (2010) Aptamers as therapeutics. Nat Rev Drug Discov 9:537–550

    Article  CAS  Google Scholar 

  20. Kim L (2001) Riddle of biofilm resistance. Antimicrob Agents Chemother. doi:10.1128/AAC.45.4.999-1007

    Google Scholar 

  21. Laza-Knoerr AL, Gref R, Couvreur P (2010) Cyclodextrins for drug delivery. J Drug Target 18:645–656

    Article  CAS  Google Scholar 

  22. Mah TFC, Toole GAO (2001) Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol 9:34–39

    Article  CAS  Google Scholar 

  23. Merga Y, Campbell BJ, Rhodes JM (2014) Mucosal barrier, bacteria and inflammatory bowel disease: possibilities for therapy. Dig Dis 32:475–483

    Article  Google Scholar 

  24. Mikalsen T, Gerits N, Moens U (2006) Inhibitors of signal transduction protein kinases as targets for cancer therapy. Biotechnol Annu Rev 12:153–223

    Article  CAS  Google Scholar 

  25. Mohanraj V, Chen Y (2006) Nanoparticles—a review. Trop J Pharm Res 5:561–573

    Google Scholar 

  26. Molema G (2001) Drug targeting: basic concepts and novel advances. In: Molema G, Meijer DKF (eds) Drug targeting: organ-specific strategies, vol 12. Wiley-VCH Verlag GmbH, Weinheim. doi:10.1002/352760006X.ch1

    Chapter  Google Scholar 

  27. Mudshinge SR, Deore AB, Patil S, Bhalgat CM (2011) Nanoparticles: emerging carriers for drug delivery. Saudi Pharm J 19:129–141

    Article  CAS  Google Scholar 

  28. Murphy DJ, Sankalia MG, Loughlin RG, Donnelly RF, Jenkins MG, Mccarron PA (2012) Physical characterisation and component release of poly(vinyl alcohol)-tetrahydroxyborate hydrogels and their applicability as potential topical drug delivery systems. Int J Pharm 423:326–334

    Article  CAS  Google Scholar 

  29. Ni X et al (2011) Nucleic acid aptamers: clinical applications and promising new horizons. Curr Med Chem 18:4206–4214

    Article  CAS  Google Scholar 

  30. Pagès JM, Amaral L (2009) Mechanisms of drug efflux and strategies to combat them: challenging the efflux pump of Gram-negative bacteria. Biochim Biophys Acta 1794:826–833

    Article  Google Scholar 

  31. Patel MP, Churchman ST, Cruchley AT, Braden M, Williams DM (2013) Delivery of macromolecules across oral mucosa from polymeric hydrogels is enhanced by electrophoresis (iontophoresis). Dent Mater 29:e299–e307

    Article  CAS  Google Scholar 

  32. Penesyan A, Gillings M, Paulsen IT (2015) Antibiotic discovery: combatting bacterial resistance in cells and in biofilm communities. Molecules 20:5286–5298

    Article  CAS  Google Scholar 

  33. Peppas NA, Bures P, Leobandung W, Ichikawa H (2000) Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm 50:27–46

    Article  CAS  Google Scholar 

  34. Petrelli F, Borgonovo K, Cabiddu M, Lonati V, Barni S (2012) Relationship between skin rash and outcome in non-small-cell lung cancer patients treated with anti-EGFR tyrosine kinase inhibitors: a literature-based meta-analysis of 24 trials. Lung Cancer 78:8–15

    Article  Google Scholar 

  35. Ramsey JD, Flynn NH (2015) Cell-penetrating peptides transport therapeutics into cells. Pharmacol Ther. doi:10.1016/j.pharmthera.2015.07.003

    Google Scholar 

  36. Rigon RB et al (2015) Nanotechnology-based drug delivery systems for melanoma antitumoral therapy: a review. BioMed Res Int article ID 841817. doi: 10.1155/2015/841817.

  37. Sanders N, Rudolph C, Braeckmans K, De Smedt SC, Demeester J (2009) Extracellular barriers in respiratory gene therapy. Adv Drug Deliv Rev 61:115–127

    Article  CAS  Google Scholar 

  38. Sigurdssona HH, Kirchb J, Lehrb CM (2013) Mucus as a barrier to lipophilic drugs. Int J Pharm 453:56–64

    Article  Google Scholar 

  39. Singh M, Sharma R, Banerjee UC (2002) Biotechnological applications of cyclodextrins. Biotechnol Adv 20:341–359

    Article  CAS  Google Scholar 

  40. Smeden JV, Janssens M, Gooris GS, Bouwstra JA (2014) The important role of stratum corneum lipids for the cutaneous barrier function. Biochim Biophys Acta 1841:295–313

    Article  Google Scholar 

  41. Sun J, Deng Z, Yan A (2014) Bacterial multidrug efflux pumps: mechanisms, physiology and pharmacological exploitations. Biochem Biophys Res Commun 453:254–267

    Article  CAS  Google Scholar 

  42. Tan S, Wu T, Zhang D, Zhang Z (2015) Cell or cell membrane-based drug delivery systems. Theranostics 5:863–881

    Article  CAS  Google Scholar 

  43. Thomas S, Shanks R, Sarathchandran C (2013) In: Andrew W (ed) Nanostructured polymer blends, 1st edn. Elsevier, Oxford

    Google Scholar 

  44. Tiwari G et al (2012) Drug delivery systems: an updated review. Int J Pharm Investig 2:2–11

    Article  Google Scholar 

  45. Torchilin VP (2014) Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery. Nat Rev Drug Discov 13:813–827

    Article  CAS  Google Scholar 

  46. Tse MT (2013) Regulatory watch: antisense approval provides boost to the field. Nat Rev Drug Discov 12 doi:10.1038/nrd3963

  47. Valle EMMD (2004) Cyclodextrins and their uses: a review. Process Biochem 39:1033–1046

    Article  Google Scholar 

  48. Wolf JP et al (2000) Topical treatment with ¨liposomes containing T4 endonuclease V protects human skin in vivo from ultraviolet-induced upregulation of interleukin-10 and tumor necrosis factor-\( \alpha \). J Invest Dermatol 114:149–156

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Biosciences and Biotechnology, Chhatrapati Shahu Ji Maharaj University, Kanpur, UP, India

    Varsha Gupta

  2. George Washington University, Washington DC, USA

    Manjistha Sengupta

  3. Orthopaedics Unit, Community Health Centre, Kanpur, UP, India

    Jaya Prakash

  4. School of Life sciences, Jawaharlal Nehru University, New Delhi, India

    Baishnab Charan Tripathy

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  1. Varsha Gupta
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  2. Manjistha Sengupta
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  3. Jaya Prakash
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  4. Baishnab Charan Tripathy
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Gupta, V., Sengupta, M., Prakash, J., Tripathy, B.C. (2017). Drug Targeting and Delivery. In: Basic and Applied Aspects of Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-10-0875-7_13

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